Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF ACUTE AND REPEATED ADMINISTRATION OF CITALOPRAM ON EXTRACELLULAR LEVELS OF SEROTONIN IN RAT-BRAIN
Autore:
MORET C; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81100 CASTRES FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 295, anno: 1996,
pagine: 189 - 197
SICI:
0014-2999(1996)295:2-3<189:EOAARA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY-MOVING RATS; INVIVO MICRODIALYSIS; 5-HT AUTORECEPTORS; RELEASE; HYPOTHALAMUS; INHIBITORS; AGONISTS; DRUG;
Keywords:
5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); 5-HT UPTAKE INHIBITOR; ANTIDEPRESSANT; MICRODIALYSIS; HYPOTHALAMUS, RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Moret e M. Briley, "EFFECTS OF ACUTE AND REPEATED ADMINISTRATION OF CITALOPRAM ON EXTRACELLULAR LEVELS OF SEROTONIN IN RAT-BRAIN", European journal of pharmacology, 295(2-3), 1996, pp. 189-197

Abstract

The effects of acute (2 days) and repeated (21 days) administration (50 mg/kg in the diet) of the selective serotonin (5-HT, 5-hydroxytryptamine) reuptake inhibitor, citalopram, on extracellular levels of 5-HTand their modulation by terminal autoreceptors in the hypothalamus offreely moving rats were compared in vivo by microdialysis. When studied without washout, extracellular levels of 5-HT were increased by both acute and repeated citalopram administration. In rats treated repeatedly, extracellular 5-HT levels were 43% (but not significantly) greater than in those treated acutely. Extracellular levels of 5-HT in control and citalopram-treated rats were similar when measured after 24 h washout. The enhancing effect of non-selective serotonergic autoreceptor antagonists, methiothepin (100 mu M) or 1-(1-naphthyl)piperazine (NP) (10 mu M), administered through the microdialysis probe, after 24 hwashout, was similar in both control and chronically treated groups. These results suggest that repeated administration of citalopram followed by a washout of 24 h does not lead to desensitization of the terminal autoreceptor as measured in vivo in contrast to the effects we have shown previously in vitro. In rats treated chronically with citalopram without washout, methiothepin had a greater maximal effect on 5-HT outflow in comparison to rats receiving acute citalopram treatment. This finding suggests that a 5-HT autoreceptor antagonist or a combination of such a drug with a 5-HT uptake inhibitor would produce a greaterincrease of extracellular levels of 5-HT in hyposerotonergic states such as depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:09:18