Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF K-HT1A RECEPTORS( CHANNEL BLOCKERS AND OPENERS ON ANTINOCICEPTION INDUCED BY AGONISTS OF 5)
Autore:
ROBLES LI; BARRIOS M; DELPOZO E; DORDAL A; BAEYENS JM;
Indirizzi:
UNIV GRANADA,SCH MED,DEPT PHARMACOL,AVE MADRID 11 E-18012 GRANADA SPAIN UNIV GRANADA,SCH MED,DEPT PHARMACOL E-18012 GRANADA SPAIN UNIV GRANADA,SCH MED,INST NEUROSCI E-18012 GRANADA SPAIN LABS DR ESTEVE SA,RES CTR E-08026 BARCELONA SPAIN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 295, anno: 1996,
pagine: 181 - 188
SICI:
0014-2999(1996)295:2-3<181:EOKRCB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; DORSAL RAPHE NEURONS; MORPHINE ANALGESIA; NOCICEPTIVE SENSITIVITY; RAT; MICE; SEROTONIN; SUBTYPES; SYSTEMS; NUCLEUS;
Keywords:
ANTINOCICEPTION; 5-HT1A RECEPTOR; 8-OH-DPAT ((+)-8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); ATP-SENSITIVE K+ CHANNEL; SULFONYLUREA; GLIQUIDONE; CROMAKALIM; RECEPTOR BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
L.I. Robles et al., "EFFECTS OF K-HT1A RECEPTORS( CHANNEL BLOCKERS AND OPENERS ON ANTINOCICEPTION INDUCED BY AGONISTS OF 5)", European journal of pharmacology, 295(2-3), 1996, pp. 181-188

Abstract

The modulation by K+ channel-acting drugs of the antinociceptive effect of several 5-HT1A receptor agonists was examined with the hot platetest in mice. All the 5-HT1A receptor agonists tested induced dose-dependent antinociception, the order of potency being (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT) > buspirone greater than or equal to lesopitron greater than or equal to tandospirone. The blockers of ATP-sensitive K+ channels (K-ATP) gliquidone and glipizide (1-4 and16-64 mu g/mouse i.c.v., respectively) reduced the antinociceptive effect of 8-OH-DPAT, whereas cromakalim (32-64 mu g/mouse i.c.v.), an opener of K-ATP channels, enhanced the effect. In contrast, 4-aminopyridine (25-250 ng/mouse i.c.v.) and tetraethylammonium (10-20 mu g/mouse i.c.v.), which antagonize several non-ATP-dependent K+ conductances, were inactive. The same results were found with other agonists of 5-HT1A receptors (lesopitron, buspirone and tandospirone): gliquidone inhibited whereas cromakalim increased their antinociceptive effects. None of the K+ channel-acting drugs modified the binding of [H-3]8-OH-DPAT to hippocampal membranes, whereas all the 5-HT1A receptor agonists displaced the ligand. These results suggest that ATP-sensitive K+ conductances are involved in the antinociception induced by agonists of 5-HT1A receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:54:24