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Titolo:
REDUCTION OF LIPOIC ACID BY LIPOAMIDE DEHYDROGENASE
Autore:
BIEWENGA GP; DORSTIJN MA; VERHAGEN JV; HAENEN GRMM; BAST A;
Indirizzi:
FREE UNIV AMSTERDAM,DEPT PHARMACOCHEM,LEIDEN AMSTERDAM CTR DRUG RES,DIV MOLEC PHARMACOL 1081 HV AMSTERDAM NETHERLANDS
Titolo Testata:
Biochemical pharmacology
fascicolo: 3, volume: 51, anno: 1996,
pagine: 233 - 238
SICI:
0006-2952(1996)51:3<233:ROLABL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDROLIPOIC ACID; DIABETIC RATS; ANTIOXIDANT; METABOLISM;
Keywords:
LIPOIC ACID; DIHYDROLIPOIC ACID; THIOCTIC ACID; LIPOAMIDE DEHYDROGENASE; ANTIOXIDANT; ENZYMATIC REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G.P. Biewenga et al., "REDUCTION OF LIPOIC ACID BY LIPOAMIDE DEHYDROGENASE", Biochemical pharmacology, 51(3), 1996, pp. 233-238

Abstract

Racemic lipoic acid is therapeutically applied in pathologies in which free radicals are involved. The in vivo reduction of lipoic acid mayplay an essential role in its antioxidant effect. It was found that mitochondrial lipoamide dehydrogenase (LipDH, EC 1.8.1.4.) reduces the R-enantiomer 28 times faster than the S-enantiomer of lipoic acid. Moreover, it was observed that the metabolites of lipoic acid, bisnor-, tetranor-, and beta-lipoic acid are poor substrates of LipDH. S-lipoic acid inhibits the reduction of the R enantiomer only at relatively high concentrations. The reduction of R-lipoic acid by mitochondria-rich tissues may proceed smoothly, even if the racemic mixture is applied. This is of importance in elucidating the molecular mechanism of the pharmacotherapeutic effect of lipoic acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:22:09