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Titolo:
CLINICAL AND NEUROPSYCHOLOGICAL DIFFERENCES BETWEEN PATIENTS WITH EARLIER AND LATER ONSET OF ALZHEIMERS-DISEASE - A CERAD ANALYSIS .12.
Autore:
KOSS E; EDLAND S; FILLENBAUM G; MOHS R; CLARK C; GALASKO D; MORRIS JC;
Indirizzi:
CASE WESTERN RESERVE UNIV HOSP,ALZHEIMERS CTR,12200 FAIRHILL RD CLEVELAND OH 44120 UNIV WASHINGTON SEATTLE WA 98195 DUKE UNIV,MED CTR DURHAM NC 00000 MT SINAI BRONX VET ADM MED CTR NEW YORK NY 00000 UNIV PENN PHILADELPHIA PA 19104 UNIV CALIF SAN DIEGO LA JOLLA CA 92093 WASHINGTON UNIV,SCH MED ST LOUIS MO 00000
Titolo Testata:
Neurology
fascicolo: 1, volume: 46, anno: 1996,
pagine: 136 - 141
SICI:
0028-3878(1996)46:1<136:CANDBP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINI-MENTAL STATE; PROGRESSION; DEMENTIA; PREDICTORS; IMPAIRMENT; MEMORY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Koss et al., "CLINICAL AND NEUROPSYCHOLOGICAL DIFFERENCES BETWEEN PATIENTS WITH EARLIER AND LATER ONSET OF ALZHEIMERS-DISEASE - A CERAD ANALYSIS .12.", Neurology, 46(1), 1996, pp. 136-141

Abstract

To determine whether the age of onset of Alzheimer's disease (AD) is related to the expression and rate of decline of this disorder, we examined the clinical and neuropsychological performance of 421 patients entered into the Consortium to Establish a Registry for Alzheimer's Disease and followed annually for up to 4 years. Statistical analyses were based on multivariable logistic regression analysis for dichotomousclinical measures and multivariable linear regression analysis for psychometric measures. All analyses examined the effect of age after controlling for gender, education, and stage of dementia. Clinical information obtained on entry into the study indicated that younger patientsperformed more poorly on measures of language and concentration, and older patients performed more poorly on measures of memory and orientation. On neuropsychological measures at entry, younger patients performed more poorly on praxis and had significantly higher scores on confrontation naming. Younger age predicted a significantly faster rate of progression for all neuropsychological measures. These findings support the concept of age-related clinical subtypes of AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:25:30