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Titolo:
THE SPECTRUM OF BEHAVIORAL-CHANGES IN ALZHEIMERS-DISEASE
Autore:
MEGA MS; CUMMINGS JL; FIORELLO T; GORNBEIN J;
Indirizzi:
W LOS ANGELES VET AFFAIRS MED CTR,NEUROBEHAV UNIT,11301 WILSHIRE BLVD,BLDG 256B,116AF LOS ANGELES CA 90073 W LOS ANGELES VET AFFAIRS MED CTR,PSYCHIAT SERV,BEHAV NEUROSCI SECT LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT & BIOBEHAV SCI LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOMATH,BIOMATH CONSULTING UNIT LOS ANGELES CA 90024
Titolo Testata:
Neurology
fascicolo: 1, volume: 46, anno: 1996,
pagine: 130 - 135
SICI:
0028-3878(1996)46:1<130:TSOBIA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-SYMPTOMS; SENILE DEMENTIA; PREDICTORS; SCALE; PSYCHOPATHOLOGY; HALLUCINATIONS; TROUBLESOME; DISTURBANCE; DEPRESSION; DELUSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Mega et al., "THE SPECTRUM OF BEHAVIORAL-CHANGES IN ALZHEIMERS-DISEASE", Neurology, 46(1), 1996, pp. 130-135

Abstract

We investigated the range of behavioral abnormalities in patients with Alzheimer's disease (AD) compared with normal age-matched control subjects. The range of behavioral disturbances manifested and the relationship between specific abnormalities with the level of cognitive impairment have not been established. Fifty consecutive outpatients with mild (n = 17), moderate (n = 20), and severe (n = 13) AD and 40 age-matched nor mal controls were evaluated for behavioral abnormalities occurring in the month preceding the interview. The caregivers of the patients and the spouses of the control subjects were interviewed with theNeuropsychiatric Inventory (NPI). The frequency and severity of the following 10 behaviors were assessed: delusions, hallucinations, agitation, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability, and aberrant motor behavior. Correlations among these 10 behaviors and their relationship with cognitive impairment were also investigated. Eighty-eight percent of AD patients had measurable behavioral changes. All 10 behaviors were significantly increased in the AD patients compared with normal subjects. The most common behavior was apathy, which was exhibited by 72% of patients, followed by agitation (60%), anxiety (48%), irritability (42%), dysphoria and aberrant motor behavior (both 38%), disinhibition (36%), delusions (22%), and hallucinations (10%). Agitation, dysphoria, apathy, and aberrant motor behavior were significantly correlated with cognitive impairment.

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Documento generato il 10/07/20 alle ore 00:18:25