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Titolo:
HUMAN MONOCYTE CHEMOTACTIC PROTEIN-2 AND PROTEIN-3 - STRUCTURAL AND FUNCTIONAL COMPARISON WITH MCP-1
Autore:
PROOST P; WUYTS A; VANDAMME J;
Indirizzi:
CATHOLIC UNIV LEUVEN,REGA INST MED RES,MINDERBROEDERSSTR 10 B-3000 LOUVAIN BELGIUM
Titolo Testata:
Journal of leukocyte biology
fascicolo: 1, volume: 59, anno: 1996,
pagine: 67 - 74
SICI:
0741-5400(1996)59:1<67:HMCPAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BLOOD MONONUCLEAR LEUKOCYTES; ACTIVATING FACTOR MCAF; SMOOTH-MUSCLE CELLS; AMINO-ACID ANALYSIS; CHEMOATTRACTANT PROTEIN-1; GENE-EXPRESSION; MOLECULAR-CLONING; ENDOTHELIAL-CELLS; MESSENGER-RNA;
Keywords:
CYTOKINE; CHEMOKINE; SERPENTINES; CHEMOTAXIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
119
Recensione:
Indirizzi per estratti:
Citazione:
P. Proost et al., "HUMAN MONOCYTE CHEMOTACTIC PROTEIN-2 AND PROTEIN-3 - STRUCTURAL AND FUNCTIONAL COMPARISON WITH MCP-1", Journal of leukocyte biology, 59(1), 1996, pp. 67-74

Abstract

Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens, MCP-1 levels are enhanced during infection and inflammation, which are characterized by leukocyte infiltration, In vitro, MCPs are chemotactic for a distinct spectrum of targetcells and show different specific biological activities depending on the cell type and the chemokine tested, MCP-3 has the broadest range in that it activates monocytes, dendritic cells, lymphocytes, natural killer cells, eosinophils, basophils, and neutrophils, The most sensitive cells to all three MCPs are lymphocytes and monocytes, MCP-1 is a potent basophil activator but does not attract eosinophils, whereas, athigher concentrations, MCP-2 also stimulates both eosinophils and basophils, The signal transduction of MCPs on monocytes involves at leasttwo G protein-linked C-C chemokine receptors: C-C CKR-1 binds MCP-3 and C-C CKR-2 binds MCP-1 and MCP-S but not MCP-2. Receptor binding leads to enhanced [Ca2+](i) for all chemokines except for MCP-2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:29:05