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Titolo:
USE OF ENDOGENOUS, STABLE LEAD ISOTOPES TO DETERMINE RELEASE OF LEAD FROM THE SKELETON
Autore:
SMITH DR; OSTERLOH JD; FLEGAL AR;
Indirizzi:
UNIV CALIF SANTA CRUZ,APPL SCI BLDG,ROOM 254A SANTA CRUZ CA 95064 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94110
Titolo Testata:
Environmental health perspectives
fascicolo: 1, volume: 104, anno: 1996,
pagine: 60 - 66
SICI:
0091-6765(1996)104:1<60:UOESLI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYSIOLOGICALLY BASED MODELS; BONE-SEEKING ELEMENTS; MASS-SPECTROMETRY; BLOOD LEAD; HUMAN TISSUES; EXPOSURE; IDENTIFICATION; MOBILIZATION; CHILDREN; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Smith et al., "USE OF ENDOGENOUS, STABLE LEAD ISOTOPES TO DETERMINE RELEASE OF LEAD FROM THE SKELETON", Environmental health perspectives, 104(1), 1996, pp. 60-66

Abstract

The stable lead isotope methodology can be used to study the release of lead from bone into the circulation because of its potential to distinguish circulatory lead from ''older'' and isotopically different skeletal lead that may have been accumulated years or decades earlier. Here we report the initial results from a larger ongoing study that evaluates the skeleton as a source of lead to the circulation in environmentally exposed human subjects. Lead concentrations and stable lead isotopic compositions were measured in blood and trabecular bone samplesobtained from five patients who underwent total hip or knee joint replacement. All subjects contained low blood (1-6 mu g/dl) and bone (0.6-7 mu g/g dry weight) lead concentrations typical of environmentally exposed individuals. There were relatively large differences in the lead isotopic compositions between the paired blood and bone samples fromeach subject. These isotropic differences are attributed to differences in the lead isotopic compositions of past versus current lead exposures and to the long elimination half-life of lead in the skeleton compared to lead in the circulation. Based on these data, we determined that the skeleton contributed 40-70% of the lead in the blood of these subjects. This initial study demonstrates the utility of the stable lead isotope methodology for investigating the release of lead from the skeleton. It also shows that the skeleton can be an important endogenous source of lead exposure in environmentally exposed humans.

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Documento generato il 26/09/20 alle ore 03:46:47