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Titolo:
INCIDENCE AND PROGNOSTIC-SIGNIFICANCE OF T(14-18) TRANSLOCATION IN FOLLICLE CENTER CELL LYMPHOMA OF LOW AND HIGH-GRADE - A REPORT FROM SOUTHERN SWEDEN
Autore:
JOHNSON A; BRUN A; DICTOR M; RAMBECH E; AKERMAN M; ANDERSON H;
Indirizzi:
UNIV LUND HOSP,DEPT ONCOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT PATHOL S-22185 LUND SWEDEN UNIV LUND HOSP,SO SWEDISH REG TUMOR REGISTRY S-22185 LUND SWEDEN
Titolo Testata:
Annals of oncology
fascicolo: 8, volume: 6, anno: 1995,
pagine: 789 - 794
SICI:
0923-7534(1995)6:8<789:IAPOTT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; NON-HODGKINS-LYMPHOMA; 14-18 TRANSLOCATION; PROTEIN EXPRESSION; 18) TRANSLOCATION; FIXED TISSUE; BCL-2 GENE; REARRANGEMENT; FROZEN; BLOOD;
Keywords:
BCL-2 REARRANGEMENT; FOLLICLE CENTER CELL LYMPHOMA; HISTOPATHOLOGIC GRADE; PROGNOSIS; T(14-18) TRANSLOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Johnson et al., "INCIDENCE AND PROGNOSTIC-SIGNIFICANCE OF T(14-18) TRANSLOCATION IN FOLLICLE CENTER CELL LYMPHOMA OF LOW AND HIGH-GRADE - A REPORT FROM SOUTHERN SWEDEN", Annals of oncology, 6(8), 1995, pp. 789-794

Abstract

Background: The t(14;18)(q21;q32) is the most common recurrent genetic defect in follicle center cell lymphoma (FCC). Conflicting reports exist in regard to a possible prognostic significance for the translocation. Patients and methods: In a single center, 102 patients with either low-grade (n = 50) or high-grade (n = 52) FCC (Kiel classification)and a median follow-up of 82 months were retrospectively studied to determine survival in relation to t(14;18) as shown by either PCR of the bcl-2 rearrangement in paraffinized tissue or karyotype analysis. Results: t(14; 18) was detected in 30 of 50 (60%) low grade FCC and in 12 of 52 (23%) high-grade FCC. The presence of the t(14; 18) was not related to morphologic bone marrow involvement or other clinical parameters, but it was related to age: in low-grade FCC, patients with t(14;18) were an average of 17 years younger (p = 0.002) than those without the translocation. In the group with high-grade histology, 30% survived beyond 60 months regardless of t(14;18) status (p = 0.92). Patients with low-grade histology and t(14;18) fared better than those without,irrespective of age (p = 0.01). No significant difference in disease-free survival related to t(14;18) was found in either low-or high-grade FCC. Conclusions: The incidence of t(14;18) is in accord with that of other European reports. T(14;18) does not define a prognostic subsetof high-grade FCC, but is significantly correlated with a better survival in low-grade FCC. The association of t(14;18) with younger age and indolent lymphoma is perplexing in light of recent findings of an age-related increase in t(14;18) in normal subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:20:04