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Titolo:
BLOOD-PRESSURE TREATMENT SLOWS THE PROGRESSION OF CAROTID STENOSIS INPATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION
Autore:
SUTTONTYRRELL K; WOLFSON SK; KULLER LH;
Indirizzi:
UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL,130 DESOTO ST PITTSBURGH PA 15261 UNIV PITTSBURGH,SCH MED,DEPT SURG PITTSBURGH PA 15261 UNIV PITTSBURGH,MONTEFIORE HOSP PITTSBURGH PA 15213
Titolo Testata:
Stroke
fascicolo: 1, volume: 25, anno: 1994,
pagine: 44 - 50
SICI:
0039-2499(1994)25:1<44:BTSTPO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ATHEROSCLEROSIS; ULTRASONOGRAPHY; ULTRASOUND; VARIABILITY; PATTERNS;
Keywords:
CAROTID ARTERY DISEASE; HYPERTENSION; STENOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Suttontyrrell et al., "BLOOD-PRESSURE TREATMENT SLOWS THE PROGRESSION OF CAROTID STENOSIS INPATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION", Stroke, 25(1), 1994, pp. 44-50

Abstract

Background and Purpose The Systolic Hypertension in the Elderly Program (SHEP) was a randomized trial testing the efficacy of treating systolic hypertension in older adults. A significant reduction in stroke risk was observed among participants assigned to active treatment. Serial carotid duplex scans were performed on 129 participants at the University of Pittsburgh center, and rates of progression and regression of carotid stenosis were observed. Methods Changes in blood flow velocity ratios were used to detect progression because they can be reliablymeasured and their relation to degree of residual lumen is known. Progression required the development of a 40% to 50% diameter stenosis when stenosis was not initially present or, if already present, further reduction in the lumen diameter. Regression required the absence of a 40% to 50% diameter stenosis when stenosis was initially present or a stenosis significantly less severe than that initially seen. Results Progression occurred in 22% (28/129) of participants and regression in 16% (8/49). Progression of carotid stenosis occurred more often among participants randomized to placebo as compared with active treatment (31% versus 14%, P=.020). All eight patients exhibiting regression wererandomized to active treatment. In multivariate analysis, participants assigned to placebo had 4.3 times greater odds of progressing than participants assigned to active treatment. Other factors significantly related to progression were higher degree of plaque at baseline, low high-density lipoprotein-3, high lipoprotein(a), and younger age. Conclusions Treating systolic hypertension appears to slow progression of carotid stenosis. Similar effects occurring in the intracranial vesselsmay be one reason for the substantial decrease in stroke among SHEP participants assigned to active treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:36:04