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Titolo:
DESENSITIZATION AND INTERNALIZATION OF ADENOSINE A(1) RECEPTORS IN RAT-BRAIN BY IN-VIVO TREATMENT WITH R-PIA - INVOLVEMENT OF COATED VESICLES
Autore:
RUIZ A; SANZ JM; GONZALEZCALERO G; FERNANDEZ M; CUBERO AA; ROS M;
Indirizzi:
UNIV CASTILLA LA MANCHA,FAC CIENCIAS QUIM,AREA BIOQUIM E-13071 CIUDADREAL SPAIN UNIV CASTILLA LA MANCHA,FAC CIENCIAS QUIM,AREA BIOQUIM E-13071 CIUDADREAL SPAIN
Titolo Testata:
Biochimica et biophysica acta. Molecular cell research
fascicolo: 1, volume: 1310, anno: 1996,
pagine: 168 - 174
SICI:
0167-4889(1996)1310:1<168:DAIOAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; MESSENGER-RNA LEVELS; BETA-2-ADRENERGIC RECEPTOR; PHOSPHORYLATION SITES; DISTINCT PATHWAYS; DOWN-REGULATION; BOVINE BRAIN; G-PROTEINS; AGONIST; BINDING;
Keywords:
ADENOSINE A(1) RECEPTOR; DESENSITIZATION; INTERNALIZATION; COATED VESICLE; PHENYLISOPROPYL ADENOSINE; RAT BRAIN; ADENYLYL CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Ruiz et al., "DESENSITIZATION AND INTERNALIZATION OF ADENOSINE A(1) RECEPTORS IN RAT-BRAIN BY IN-VIVO TREATMENT WITH R-PIA - INVOLVEMENT OF COATED VESICLES", Biochimica et biophysica acta. Molecular cell research, 1310(1), 1996, pp. 168-174

Abstract

Chronic treatment of rats with R-PIA 'in vivo' desensitized adenosineA(1) receptor-mediated inhibition of adenylyl cyclase in brain plasmamembranes and increased basal and forskolin-stimulated adenylyl cyclase. The adenosine A(1) receptor agonist CHA (cyclohexyl adenosine) inhibited forskolin-stimulated adenylyl cyclase in synaptic plasma membranes from control rats but failed to do so in membranes isolated from rats treated with R-PIA. This loss of response was accompanied with a significant decrease in both, total number of adenosine A(1) receptors and steady-state level of alpha-G(i) in synaptic plasma membranes. An increase in the steady-state level of alpha-G(s) in synaptic plasma membranes was also observed by R-PIA treatment. Concurrently, a significant increase of adenosine A(1) receptors was observed in microsomes and coated vesicles. These results demonstrate adenosine A(1) receptor desensitization in rat brain by 'in vivo' treatment with R-PIA and suggest a role for coated vesicles in the internalization of G-protein coupled receptors.

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Documento generato il 07/07/20 alle ore 22:35:43