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Titolo:
CERAMIDE INDUCES APOPTOSIS IN CULTURED MESENCEPHALIC NEURONS
Autore:
BRUGG B; MICHEL PP; AGID Y; RUBERG M;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM U289,LAB PHYSIOPATHOL & PATHOGENESE MALAD NEURODEGENER F-75651 PARIS 13 FRANCE HOP LA PITIE SALPETRIERE,INSERM U289,LAB PHYSIOPATHOL & PATHOGENESE MALAD NEURODEGENER F-75651 PARIS 13 FRANCE
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 66, anno: 1996,
pagine: 733 - 739
SICI:
0022-3042(1996)66:2<733:CIAICM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ACTIVATED PROTEIN-KINASE; PROGRAMMED CELL-DEATH; NERVE GROWTH-FACTOR; HL-60 CELLS; SPHINGOMYELIN TURNOVER; DOPAMINERGIC-NEURONS; FACTOR-ALPHA; GENE CED-3; RAT;
Keywords:
PROGRAMMED CELL DEATH; SPHINGOMYELIN SIGNAL TRANSDUCTION; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
B. Brugg et al., "CERAMIDE INDUCES APOPTOSIS IN CULTURED MESENCEPHALIC NEURONS", Journal of neurochemistry, 66(2), 1996, pp. 733-739

Abstract

The death of dopaminergic and other neurons in primary cultures of the mesencephalon could be induced by treatment with ceramide, as in lymphocytes where it mediates activation by the cytokines tumor necrosis factor-alpha and interleukin-1 beta of a novel sphingomyelin-dependentsignaling pathway leading to apoptosis, The morphological hallmarks of this form of cell death-bleb formation, cell body shrinkage, nuclearchromatin condensation, and fragmentation-were observed in degenerating neurons, Internucleosomal DNA degradation could also be evidenced by gel electrophoresis. The C-2 and C-6 analogues as well as native ceramide, administered in a dodecane suspension, had a similar effect, whereas the closely related C-2-dihydroceramide, which lacks the 4-5 trans double bond in the sphingosine chain, failed to induce apoptosis. Neuronal death could be delayed by serum factors, dibutyryl cyclic AMP,and the protein synthesis inhibitor cycloheximide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:44:03