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Titolo:
ESTROGEN ALTERS MPTP-INDUCED NEUROTOXICITY IN FEMALE MICE - EFFECTS ON STRIATAL DOPAMINE CONCENTRATIONS AND RELEASE
Autore:
DLUZEN DE; MCDERMOTT JL; LIU BJ;
Indirizzi:
NE OHIO UNIV,COLL MED,DEPT ANAT,4209 STATE ROUTE 44,POB 95 ROOTSTOWN OH 44272 EDWIN SHAW REHABIL HOSP,DEPT MED AKRON OH 00000
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 66, anno: 1996,
pagine: 658 - 666
SICI:
0022-3042(1996)66:2<658:EAMNIF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; RAT STRIATUM; UPTAKE SITES; CYCLE; ESTRADIOL; BRAIN; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; PROGESTERONE; RECEPTORS; 1-METHYL-4-PHENYLPYRIDINIUM;
Keywords:
L-DOPA; NEUROTOXIN; NEUROPROTECTANT; NIGROSTRIATAL SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Dluzen et al., "ESTROGEN ALTERS MPTP-INDUCED NEUROTOXICITY IN FEMALE MICE - EFFECTS ON STRIATAL DOPAMINE CONCENTRATIONS AND RELEASE", Journal of neurochemistry, 66(2), 1996, pp. 658-666

Abstract

The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrationsof C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopaminerelease values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the MPTP-treated C57Bl mice. DOPAC release rates were similar to that of dopamine in these C57Bl mice. In the CD-1 mice estrogen also produced a significant increase in L-DOPA-evoked dopamine release; however, this response was unaltered by MPTP treatment, A significant increase in L-DOPA-evoked DOPAC output was obtained only for estrogen-treated CD-1 mice. Both strains show very similar responses to the estrogen treatment, but differential responses of dopamine release to L-DOPA between the C57Bl and CD-1 mice were obtained with regard to the interactive effects of estrogen and MPTP. Our results suggest thatin addition to its role as modulator, estrogen may also function as aneuroprotectant against MPTP neurotoxicity of the nigrostriatal dopaminergic system in the C57Bl mouse.

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Documento generato il 13/07/20 alle ore 07:48:04