Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTAGONISM OF SEROTONIN 5-HT1A RECEPTORS POTENTIATES THE INCREASES INEXTRACELLULAR MONOAMINES INDUCED BY DULOXETINE IN RAT HYPOTHALAMUS
Autore:
ENGLEMAN EA; ROBERTSON DW; THOMPSON DC; PERRY KW; WONG DT;
Indirizzi:
ELI LILLY & CO,LILLY RES LABS,LILLY CORP CTR INDIANAPOLIS IN 46285
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 66, anno: 1996,
pagine: 599 - 603
SICI:
0022-3042(1996)66:2<599:AOS5RP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVIVO MICRODIALYSIS; BRAIN MICRODIALYSIS; FRONTAL-CORTEX; RAPHE NUCLEI; 5-HYDROXYTRYPTAMINE; INHIBITION; BLOCKADE; ABILITY; DRUGS;
Keywords:
LY 206130; 5-HT1A ANTAGONIST; 5-HT1A RECEPTORS; DULOXETINE; EXTRACELLULAR MONOAMINES; HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Engleman et al., "ANTAGONISM OF SEROTONIN 5-HT1A RECEPTORS POTENTIATES THE INCREASES INEXTRACELLULAR MONOAMINES INDUCED BY DULOXETINE IN RAT HYPOTHALAMUS", Journal of neurochemistry, 66(2), 1996, pp. 599-603

Abstract

In the current study we examined the effects of coadministration of aserotonin 5-HT1A antagonist, -(1H-indol-4-yloxy)-3-(cyclohexylamino)-2-propanol maleate (LY 206130), and a dual 5-HT and norepinephrine (NE) uptake inhibitor, duloxetine, on extracellular levels of NE, 5-HT, dopamine (DA), 5-hydroxyindoleacetic acid, and 3,4-dihydroxyphenylacetic acid in rat hypothalamus microdialysates. LY 206130 (3.0 mg/kg, s.c.) alone significantly increased NE and DA levels by 60 and 34%, respectively, without affecting 5-HT levels. Duloxetine administration at 4.0 mg/kg, i.p. alone produced no significant changes in levels of 5-HT,NE, or DA. In contrast, when LY 206130 and duloxetine were coadministered at 3.0 mg/kg, s.c. and 4.0 mg/kg, i,p,, respectively, 5-HT, NE, and DA levels increased to 5.7-, 4.8-, and threefold over their respective basal levels. These data demonstrate that antagonism of somatodendritic 5-HT1A autoreceptors and concomitant inhibition of 5-HT and NE up-take with duloxetine may promote synergistic increases in levels of extracellular 5-HT, NE, and DA in hypothalamus of conscious, freely moving rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:13:09