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Titolo:
GENETIC MODELING OF DIZYGOTIC TWINNING IN PEDIGREES OF SPONTANEOUS DIZYGOTIC TWINS
Autore:
MEULEMANS WJ; LEWIS CM; BOOMSMA DI; DEROM CA; VANDENBERGHE H; ORLEBEKE JF; VLIETINCK RF; DEROM RM;
Indirizzi:
CATHOLIC UNIV LEUVEN,UZ GASTHUISBERG O&N6,CTR HUMAN GENET,HEREST 49 B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LEUVEN,CTR HUMAN GENET B-3000 LOUVAIN BELGIUM UNIV UTAH,DEPT MED INFORMAT SALT LAKE CITY UT 84112 FREE UNIV AMSTERDAM,DEPT PSYCHON AMSTERDAM NETHERLANDS
Titolo Testata:
American journal of medical genetics
fascicolo: 3, volume: 61, anno: 1996,
pagine: 258 - 263
SICI:
0148-7299(1996)61:3<258:GMODTI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVULATION; DNA;
Keywords:
SEGREGATION ANALYSIS; PEDIGREE ANALYSIS; DIZYGOTIC TWINNING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
W.J. Meulemans et al., "GENETIC MODELING OF DIZYGOTIC TWINNING IN PEDIGREES OF SPONTANEOUS DIZYGOTIC TWINS", American journal of medical genetics, 61(3), 1996, pp. 258-263

Abstract

The inheritance of spontaneous dizygotic (DZ) twinning was investigated in 1,422 three-generation pedigrees ascertained through mothers of spontaneous DZ proband twins, DZ twinning was modelled as a trait expressed only in women, The penetrance was modelled first as a parity independent and secondly as parity dependent, The observed frequencies ofmaternal and paternal grandmothers with DZ twins differed significantly from the expectations under an X-linked mode of inheritance, Complex segregation analysis showed that the parity-independent phenotype of''having DZ twins'' was consistent with an autosomal monogenic dominant model, with a gene frequency of 0.035 and a female-specific lifetime penetrance of 0.10, Recessive, polygenic, and sporadic models were rejected, The autosomal dominant model revealed a strong robustness against a changing population prevalence and the loss of information due to the presence of same-sexed twin pairs of unknown zygosity. When DZ twinning was modelled as a parity dependent trait, the data were compatible with an autosomal dominant model with a gene frequency of 0.306 and a penetrance of 0.03 per birth for female gene carriers. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:23:16