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Titolo:
WHEN IS THE MAXIMAL EFFECT OF PRE-ADMINISTERED SYSTEMIC MORPHINE ON CARRAGEENAN EVOKED SPINAL C-FOS EXPRESSION IN THE RAT
Autore:
HONORE P; CHAPMAN V; BURITOVA J; BESSON JM;
Indirizzi:
INSERM U161,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 705, anno: 1995,
pagine: 91 - 96
SICI:
0006-8993(1995)705:1-2<91:WITMEO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-LIKE IMMUNOREACTIVITY; INDUCED INFLAMMATION; BEHAVIORAL EVIDENCE; ARTHRITIC RATS; CORD; STIMULUS; PAIN; HYPERALGESIA; NOCICEPTION; SENSITIVITY;
Keywords:
MORPHINE; C-FOS; NOCICEPTION; SPINAL CORD; TIME COURSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "WHEN IS THE MAXIMAL EFFECT OF PRE-ADMINISTERED SYSTEMIC MORPHINE ON CARRAGEENAN EVOKED SPINAL C-FOS EXPRESSION IN THE RAT", Brain research, 705(1-2), 1995, pp. 91-96

Abstract

This study evaluated, in awake rats, the time course of the expression of c-Fos in spinal cord neurons, in the IA-LS segments, at various time points after intraplantar carrageenin (0.5 h, 1 h, 1.5 h, 2 h and 2.5 h). In addition, the effects of pre-administered morphine (3 mg/kg, i.v.) on the c-Fos expression, at the various time points, were studied. Very few Fos-like immunoreactive (Fos-LI) neurons were observed 0.5 h after carrageenin. However, spinal c-Fos expression increased initially (at 1 h), in the superficial laminae (I-II) of the spinal dorsal horn, and incrementally increased both in the superficial and deep (V-VI) laminae at later time points after carrageenin. Systemic morphine did not significantly decrease the number of superficial Fos-LI neurons observed 1 h after carrageenin, whereas it significantly reduced the number of superficial Fos-LI neurons induced at 1.5 h and 2 h aftercarrageenin (58 +/- 3% and 57 +/- 10% reduction, P < 0.001, respectively). In addition, morphine reduced the number of deep Fos-LI neurons at 1.5 h and 2 h after carrageenin (86 +/- 4%, P < 0.01 and 82 +/- 8%,P < 0.001 reduction as compared to control carrageenin expression, respectively). In contrast, morphine was less efficacious in decreasing the number of Fos-LI neurons observed in the superficial and deep laminae at 2.5 h after carrageenin (34 +/- 6% and 59 +/- 6% reduction, P <0.001, respectively). Thus, the peak effect of pre-administered morphine on carrageenin evoked c-Fos expression was observed 1.5 h and 2 h after intraplantar carrageenin, with a weaker effect observed at 2.5 hafter carrageenin. The pharmacokinetic complications between the timecourse of the antinociceptive effects of morphine and c-Fos expression is discussed. These results clearly demonstrate that studies of c-Fos expression with pharmacological investigations should take into consideration this finding since one delay after the stimulation does not give a full indication of the full potential of the drug tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:06:36