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Titolo:
TIE1, A RECEPTOR TYROSINE KINASE ESSENTIAL FOR VASCULAR ENDOTHELIAL-CELL INTEGRITY, IS NOT CRITICAL FOR THE DEVELOPMENT OF HEMATOPOIETIC-CELLS
Autore:
RODEWALD HR; SATO TN;
Indirizzi:
HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV CARDIOVASC,330 BROOKLINE AVE BOSTON MA 02215 BASEL INST IMMUNOL CH-4005 BASEL SWITZERLAND ROCHE INST MOLEC BIOL,ROCHE RES CTR NUTLEY NJ 07110
Titolo Testata:
Oncogene
fascicolo: 2, volume: 12, anno: 1996,
pagine: 397 - 404
SICI:
0950-9232(1996)12:2<397:TARTKE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; PROGENITOR CELLS; STEM-CELLS; C-KIT; EXPRESSION; MOUSE; FAMILY; GENES; MEMBER; DIFFERENTIATION;
Keywords:
TIE1; RECEPTOR TYROSINE KINASE; HEMATOPOIETIC STEM CELLS; LYMPHOCYTE DEVELOPMENT; RECOMBINATION-ACTIVATING-GENE (RAG)-2-DEFICIENT MICE; COLONY-FORMING CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald e T.N. Sato, "TIE1, A RECEPTOR TYROSINE KINASE ESSENTIAL FOR VASCULAR ENDOTHELIAL-CELL INTEGRITY, IS NOT CRITICAL FOR THE DEVELOPMENT OF HEMATOPOIETIC-CELLS", Oncogene, 12(2), 1996, pp. 397-404

Abstract

The receptor tyrosine kinase Tiel is expressed in both vascular endothelial cells and immature hematopoietic cells. Expression of a common signaling molecule in distinct cellular Lineages may suggest common ancestry of these lineages in ontogeny and/or utilization of shared signaling pathways, Tie l-deficient mice carrying a targeted insertional mutation in germ line show defects in endothelial cell integrity resulting in edema and hemorrhage. To analyse the potential role of this kinase in hematopoietic cells, we have now compared hematopoietic compartments in wildtype and Tiel-deficient mice, The results show: (1) Totalcellularity is mildly reduced comparing Tie1(-/-) and wildtype fetal liver from day 15.5 of gestation, (2) In vitro colony assays and cell transfer experiments of fetal liver cells into lymphocyte-deficient recombination-activating-gene-2(-/-) mice reveal that Tie1(-/-) hematopoietic progenitor cells can generate myeloid lineages as well as T and B lymphocytes, (3) Tie1(-/-) fetal liver cells contain long-term (at least 4 months) bone marrow-reconstituting hematopoietic stem cells suggesting that this kinase is not critical for stem cell-engraftment norself-renewal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:36:50