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Titolo:
EFFECTS OF ADOPTIVE TRANSFER OF IMMUNE SPLEEN-CELLS ON WORM GROWTH AND MICROFILAREMIA IN BRUGIA-PAHANGI INFECTION IN MONGOLIAN GERBILS
Autore:
KHAN AI; HORII Y; ISHIKAWA N; NAWA Y;
Indirizzi:
MIYAZAKI MED COLL,DEPT PARASITOL MIYAZAKI 88916 JAPAN MIYAZAKI MED COLL,DEPT PARASITOL MIYAZAKI 88916 JAPAN MIYAZAKI UNIV,FAC AGR,DEPT VET INTERNAL MED MIYAZAKI 88921 JAPAN
Titolo Testata:
Journal of Helminthology
fascicolo: 4, volume: 69, anno: 1995,
pagine: 331 - 335
SICI:
0022-149X(1995)69:4<331:EOATOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
JIRDS MERIONES-UNGUICULATUS; EXPERIMENTAL FILARIASIS; PROTECTIVE IMMUNITY; MULTIPLE INFECTIONS; STAGE LARVAE; MALAYI; RESISTANCE; IMMUNOREGULATION; VACCINATION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Khan et al., "EFFECTS OF ADOPTIVE TRANSFER OF IMMUNE SPLEEN-CELLS ON WORM GROWTH AND MICROFILAREMIA IN BRUGIA-PAHANGI INFECTION IN MONGOLIAN GERBILS", Journal of Helminthology, 69(4), 1995, pp. 331-335

Abstract

Protective immunity against Brugia pahangi was examined after adoptive transfer of immune spleen cells. Spleen cells obtained from gerbils at 8 weeks post-infection (p.i.) with 100 infective larvae (L(3)) of B. pahangi were transferred into naive recipients, and then 24 h later,they were infected with 100 L, of B. pahangi. The recipients given normal spleen cells and infected by the same manner served as controls. Microfilarial counts in the circulation were monitored at designated times after infection and worm burden and the size of individual femaleworm were determined at 16 weeks p.i. to evaluate the effects of adoptive immunization. In addition, eosinophil responses and serum antibody titres were examined during the course of infection. In the control group, microfilariae first appeared in circulation at 9 weeks p.i. andcontinuously increased in number throughout the course examined. In contrast, microfilaraemia was almost completely suppressed in the groupgiven immune spleen cells. Although worm burden was comparable between the two groups, the average size of female adult worms recovered from the adoptively immunized group was significantly smaller than that from the control group. Eosinophil response was hastened and enhanced by adoptive transfer of immune spleen cells in the early stage of infection. Parasite-specific antibody response was also hastened by adoptive immunization. These results suggest that immune spleen cells could confer protective immunity mainly directed against adult B. pahangi.

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Documento generato il 27/11/20 alle ore 22:05:07