Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VARIABLE RESPONSE OF THE PERIPHERAL-CIRCULATION TO ACETYLCHOLINE IN PATIENTS WITH CORONARY-ARTERY DISEASE
Autore:
TESTA M; BIASUCCI LM; CACCIOLA M; LOMBARDO A; PENNESTRI F; LEJEMTEL TH; LOPERFIDO F;
Indirizzi:
UNIV CATTOLICA SACRO CUORE,POL A GEMELLI,IST CARDIOL,LARGO A GEMELLI 8 I-00168 ROME ITALY CATHOLIC UNIV,INST CARDIOL ROME ITALY IRCCS,CASA SOLLIEVO SOFFERENZA HOSP,DEPT CARDIOL SAN GIOVANNI ROTO ITALY
Titolo Testata:
The American journal of cardiology
fascicolo: 2, volume: 77, anno: 1996,
pagine: 149 - 153
SICI:
0002-9149(1996)77:2<149:VROTPT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; CONGESTIVE-HEART-FAILURE; MEDIATED VASODILATION; RESISTANCE VESSELS; DYSFUNCTION; ATHEROSCLEROSIS; HUMANS; MICROVASCULATURE; HYPERTENSION; RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M. Testa et al., "VARIABLE RESPONSE OF THE PERIPHERAL-CIRCULATION TO ACETYLCHOLINE IN PATIENTS WITH CORONARY-ARTERY DISEASE", The American journal of cardiology, 77(2), 1996, pp. 149-153

Abstract

The purpose of this study was to assess endothelium-mediated vasodilation in the peripheral circulation of patients with coronary artery disease who are free from hypertension, hypercholesterolemia, diabetes mellitus, and congestive heart failure. The vascular response of the superficial femoral artery to an endothelium-dependent (i.e., acetylcholine 10(-7), 10(-6), and 10(-5) mol/L) and to an endothelium-independent (i.e., nitroglycerin 10(-8) and 10(-6) mol/L) dilator was compared in 13 patients with angiographically documented coronary artery diseaseand in 7 patients with normal coronary angiograms. Vascular response was assessed by Doppler ultrasonography. Whereas the vascular responses to nitroglycerin in patients with abnormal and normal findings on coronary angiograms were similar, the responses to acetylcholine were clearly different. The ratio of mean blood flow velocity (+/- SD) measured during administration of acetylcholine 10(-6) mol/L and mannitol was significantly lower in patients with abnormal versus normal results of coronary angiography (1.15 +/- 0.35 vs 2.20 +/- 1.06; p <0.05). Thevascular response to acetylcholine 10(-5) mol/L in patients with an abnormal finding on their coronary angiogram was highly variable when compared with that in patients with normal results. Thus, in patients with angiographically proven coronary artery disease, the response of the peripheral circulation to acetylcholine is characterized by a greatvariability and a reduced sensitivity, when compared with that in patients with normal findings on coronary angiography.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 05:34:16