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Titolo:
EFFECT OF LAZAROID U-74389G ON IRON-INDUCED REDUCTION OF STRIATAL DOPAMINE METABOLISM
Autore:
WESEMANN W; SOLBACH M; NAFE R; GROTE C; SONTAG KH; RIEDERER P; JELLINGER K; MENNEL HD; CLEMENT HW;
Indirizzi:
UNIV MARBURG,INST PHYSIOL CHEM,NEUROCHEM ABT,HANS MEERWEIN STR D-35033 MARBURG GERMANY MAX PLANCK INST EXPTL MED,DEPT PHARMACOL W-3400 GOTTINGEN GERMANY UNIV WURZBURG,DEPT PSYCHIAT,DIV CLIN NEUROCHEM W-8700 WURZBURG GERMANY LAINZ HOSP,LUDWIG BOLTZMANN INST CLIN NEUROBIOL A-1130 VIENNA AUSTRIA UNIV MARBURG LAHN,MED CTR PATHOL,DEPT NEUROPATHOL MARBURG GERMANY
Titolo Testata:
Journal of neural transmission. Supplementum
fascicolo: 46, , anno: 1995,
pagine: 175 - 182
SICI:
0303-6995(1995):46<175:EOLUOI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; LIPID-PEROXIDATION; BRAINS; GLUTATHIONE; TOXICITY; NEURONS; RATS; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W. Wesemann et al., "EFFECT OF LAZAROID U-74389G ON IRON-INDUCED REDUCTION OF STRIATAL DOPAMINE METABOLISM", Journal of neural transmission. Supplementum, (46), 1995, pp. 175-182

Abstract

The substantia nigra of parkinsonian brains is reported to contain increased amounts of iron as compared with age-matched controls. Since iron might be cytotoxic via radical mechanisms, we analyzed the effect of intranigral iron infusion on the dopaminergic activity in the striatum of the rat. The striatal dopamine metabolism of the rat was followed 1, 3, and 6 weeks after unilateral intranigral iron (III) (1.5 mu g) application. A progressive decrease of extraneuronal 3.4-dihydroxyphenylacetic acid (DOPAC) levels was observed in the ipsilateral striatum by means of in vivo pulse voltammetry. The significant reduction of the DOFAC signal could be attenuated by pretreatment of the animals with the lazaroid U-74389G, applied ip 20 minutes before unilateral intranigral iron application. Our data indicate that a single iron application into the substantia nigra leads to a progressive loss of dopaminergic activity in the striatum, also observed in Parkinson patients, Furthermore, the Lazaroid U-74389G seems to be beneficial in this model of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:54:36