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Titolo:
INVOLVEMENT OF H-1 RECEPTORS IN THE CENTRAL ANTINOCICEPTIVE EFFECT OFHISTAMINE - PHARMACOLOGICAL DISSECTION BY ELECTROPHYSIOLOGICAL ANALYSIS
Autore:
BRAGA PC; SOLDAVINI E; PECILE A; SIBILIA V; NETTI C;
Indirizzi:
UNIV MILAN,SCH MED,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY
Titolo Testata:
Experientia
fascicolo: 1, volume: 52, anno: 1996,
pagine: 60 - 65
SICI:
0014-4754(1996)52:1<60:IOHRIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTHRITIC RATS; BRAIN; INJECTION; NEURONS; FIBERS;
Keywords:
HISTAMINE ANTINOCICEPTION; HISTAMINE RECEPTORS; 2-PYRIDYLETHYLAMINE; DIMAPRIT; MEPYRAMINE; ZOLANTIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Braga et al., "INVOLVEMENT OF H-1 RECEPTORS IN THE CENTRAL ANTINOCICEPTIVE EFFECT OFHISTAMINE - PHARMACOLOGICAL DISSECTION BY ELECTROPHYSIOLOGICAL ANALYSIS", Experientia, 52(1), 1996, pp. 60-65

Abstract

Intracerebroventricular (i.c.v.) administration of histamine (HA, 0.025-0.1 mu M/rat) to arthritic rats induces a dose-related inhibition of the neuronal thalamic firing evoked by peripheral noxious stimuli. To characterize the type(s) of HA receptors involved in this depressingactivity of the amine we used electrophysiological techniques to examine the effects of i.c.v. administration of H-1 and H-2 agonists and antagonists on the spontaneous and evoked nociceptive firing of the thalamic neurons in rats rendered arthritic by Freund's adjuvant. The H-1agonist 2-pyridylethylamine (0.4-1.0 mu M/rat, i.c.v) displayed a dose-dependent antinociceptive effect very similar to that of HA, while the H-2 agonist dimaprit (0.05-0.2 mu M/rat, i.c.v.) did not modify thalamic firing. Neither mepyramine (H-1 antagonist, 0.1 mu M/rat, i.c.v.) nor zolantidine (H-2 antagonist, 0.01 mu M/rat, i.c.v.) modified theevoked firing of rat thalamic neurons. When administered before HA (0.1 mu M/rat, i.c.v.) mepyramine but not zolantidine was able to inhibit the antinociceptive effect of HA. On the basis of the present electrophysiological results, we suggest that a specific interaction of histamine with H-1 receptors may be important for its antinociceptive effect on afferent peripheral inputs to the thalamus.

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Documento generato il 31/03/20 alle ore 15:29:54