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Titolo:
THE EFFECT OF NONSURGICAL PERIODONTAL AND ADJUNCTIVE MINOCYCLINE-HCL TREATMENTS ON THE ACTIVITY OF SALIVARY PROTEASES
Autore:
ATILLA G; BALCAN M; BICAKCI N; KAZANDI A;
Indirizzi:
EGE UNIV,DISHEKIMLIGI FAK,PERIODONTOL ANABILIM DALI,DEPT PERIODONTOL BORNOVA 35100 IZMIR TURKEY UNIV EGE,FAC DENT,DEPT PERIODONTOL IZMIR TURKEY UNIV EGE,DEPT CHEM IZMIR TURKEY UNIV EGE,FAC MED,DEPT DERMATOL IZMIR TURKEY
Titolo Testata:
Journal of periodontology
fascicolo: 1, volume: 67, anno: 1996,
pagine: 1 - 6
SICI:
0022-3492(1996)67:1<1:TEONPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINGIVAL CREVICULAR FLUID; COLLAGENASE ACTIVITY; TETRACYCLINE-INHIBITION; CELLULAR SOURCE; DISEASE; THERAPY; ENZYMES; ORIGIN; HUMANS; PLAQUE;
Keywords:
ADJUVANTS, PHARMACEUTICAL; PERIODONTITIS THERAPY; MINOCYCLINE THERAPEUTIC USE; PROTEASE ACTIVITY; PLANING; SCALING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Atilla et al., "THE EFFECT OF NONSURGICAL PERIODONTAL AND ADJUNCTIVE MINOCYCLINE-HCL TREATMENTS ON THE ACTIVITY OF SALIVARY PROTEASES", Journal of periodontology, 67(1), 1996, pp. 1-6

Abstract

THE PURPOSE OF THIS INVESTIGATION WAS TO EVALUATE the effect of non-surgical periodontal treatment and adjunctive systemic minocycline therapy on the level of neutral protease activity in whole saliva of adults with periodontitis. A test group of 21 adult patients with moderate to severe periodontitis was compared to a control group of 5 adults with healthy periodontium. Four test groups were examined: 1) scaling and root planing (SRP), probing depth = 4 to 5 mm; 2) SRP, PD greater than or equal to 6 mm; 3) SRP and adjunctive systemic minocycline therapy, PD = 4 to 5 mm; and 4) SRP and adjunctive systemic minocycline therapy, PD greater than or equal to 6 mm. Clinical parameters and levels of neutral protease in whole saliva were assessed at baseline and on the sixth week after the non-surgical periodontal treatment. Neutral protease activity was measured by spectrofluorimetric method. Statistical tests of Mann-Whitney and Spearman Rank correlation coefficient wereused in the evaluation of the mean values of measurements. The mean values of protease activity were significantly higher in the test groups than in the control group at baseline. Six weeks after non-surgical therapy, patients with 4 to 5 mm probing depth had approximate values of protease activity comparable to the control group. Hence it can be argued that these patients did not need minocycline HCL as an adjunctive therapy. However, non-surgical therapy had limited effects on both clinical parameters and enzyme activities for subjects with greater than or equal to 6 mm probing depth; on the other hand, gingival inflammation and enzyme activities were reduced significantly by the usage ofminocycline as adjunctive therapy in these patients. According to ourresults, neutral protease activity in saliva is related to probing depth and gingival bleeding index, and not related to age and epithelialcell number. For these reasons, systemic minocycline therapy might beuseful as an adjunct to non-surgical therapy in the presence of deep pockets, especially for reinfected cases. Further investigations are needed to confirm this suggestion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:14:25