Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MUSCIMOL ACTS IN DORSOMEDIAL BUT NOT PARAVENTRICULAR HYPOTHALAMIC NUCLEUS TO SUPPRESS CARDIOVASCULAR EFFECTS OF STRESS
Autore:
STOTTPOTTER EH; WILLIS LR; DIMICCO JA;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL INDIANAPOLIS IN 46202
Titolo Testata:
The Journal of neuroscience
fascicolo: 3, volume: 16, anno: 1996,
pagine: 1173 - 1179
SICI:
0270-6474(1996)16:3<1173:MAIDBN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; RATS REGULATE ANXIETY; PLUS-MAZE TEST; INDUCED TACHYCARDIA; POSTERIOR HYPOTHALAMUS; CONSCIOUS RATS; GABA RECEPTORS; HEART-RATE; RESPONSES; STIMULATION;
Keywords:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; PARAVENTRICULAR NUCLEUS; MUSCIMOL; GABA; HEART RATE; BLOOD PRESSURE; STRESS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E.H. Stottpotter et al., "MUSCIMOL ACTS IN DORSOMEDIAL BUT NOT PARAVENTRICULAR HYPOTHALAMIC NUCLEUS TO SUPPRESS CARDIOVASCULAR EFFECTS OF STRESS", The Journal of neuroscience, 16(3), 1996, pp. 1173-1179

Abstract

Both the dorsomedial hypothalamic nucleus (DMH) and the paraventricular hypothalamic nucleus (PVN) have been implicated in the neural control of the cardiovascular response to stress. We used the GABA(A) agonist muscimol to inhibit neuronal activation and attempted to identify hypothalamic nuclei required for the cardiovascular response to air stress. Chronically instrumented rats received bilateral injections of either 80 pmol of muscimol or 100 nl of saline vehicle into the DMH, thePVN, or an intermediate area (including the rostral edge of the DMH and the region between the two nuclei) and were placed immediately in arestraining tube and subjected to 20 min of air stress, In all rats, air stress after vehicle injections caused marked increases in heart rate (137 +/- 6 beats/min) and blood pressure (26 +/- 2 mmHg). Microinjection of muscimol into the DMH suppressed the heart rate and blood pressure response by 85 and 68%, respectively. Identical microinjection of muscimol into the intermediate area between the DMH and the PVN attenuated the increases in heart rate by only 46% and in blood pressure by 52%. In contrast, similar injections into the vicinity of the PVN failed to alter the cardiovascular response to air stress. These findings demonstrate that muscimol-induced inhibition of neuronal activity in the region of the DMH blocks air stress-induced increases in heart rate and arterial pressure, whereas similar treatment in the area of the PVN has no effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:53:03