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Titolo:
IN-VITRO ANALYSIS OF OPTIMAL STIMULI FOR PHASE-LOCKING AND TIME-DELAYED MODULATION OF FIRING IN AVIAN NUCLEUS LAMINARIS NEURONS
Autore:
REYES AD; RUBEL EW; SPAIN WJ;
Indirizzi:
VET AFFAIRS MED CTR,MAILSTOP 127,1660 S COLUMBIAN WAY SEATTLE WA 98108 VET AFFAIRS MED CTR SEATTLE WA 98108 UNIV WASHINGTON,SCH MED,VIRGINIA MERRILL BLOEDEL HEARING RES CTR SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MED,DIV MED GENET SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MED,DEPT NEUROL SEATTLE WA 98195
Titolo Testata:
The Journal of neuroscience
fascicolo: 3, volume: 16, anno: 1996,
pagine: 993 - 1007
SICI:
0270-6474(1996)16:3<993:IAOOSF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM AUDITORY NUCLEI; CHICK BRAIN-STEM; COCHLEAR NUCLEUS; TONOTOPIC ORGANIZATION; NERVE FIBERS; N-LAMINARIS; BARN OWL; SUPERIOR OLIVE; MAGNOCELLULARIS; PROJECTIONS;
Keywords:
NUCLEUS LAMINARIS; NUCLEUS MAGNOCELLULARIS; SOUND LOCALIZATION; DYNAMIC CLAMP; PHASE-LOCKING; OUTWARD RECTIFICATION; COINCIDENCE DETECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Reyes et al., "IN-VITRO ANALYSIS OF OPTIMAL STIMULI FOR PHASE-LOCKING AND TIME-DELAYED MODULATION OF FIRING IN AVIAN NUCLEUS LAMINARIS NEURONS", The Journal of neuroscience, 16(3), 1996, pp. 993-1007

Abstract

Neurons of the avian nucleus laminaris (NL) provide a neural substrate for azimuthal sound localization. We examined the optimal stimuli for NL neurons to maintain high discharge rates, reliable phase-locking,and sensitivity to time-delayed stimuli. Whole-cell recordings were performed in chick [embryonic days 19-21 (E19-E21)] NL neurons using anin vitro slice preparation. Variation of membrane properties along the tonotopic axis was examined, Computer-controlled intracellular current injection was used to mimic postsynaptic currents or conductances (PSCs) generated in NL neurons by the firing of nucleus magnocellularis(NM) neurons during acoustic stimulation. At various stimulus frequencies, the effects of varying the number of NM cells and PSC amplitudeson firing rate and phase-locking were examined. During high-frequencystimulation, the greatest firing rate and phase-locking occurred whenthe protocol contained few NM cells that generated large PSCs. Because the stimulus-evoked unitary PSCs are small, we propose that NM cellsfire in synchrony to generate large PSCs. To mimic the arrival of PSCs during binaural stimulation, two stimulus trains were summed at different delays before injection. The firing rate of NL neurons was greatest with zero delay. A delay of half the stimulus period evoked firingthat was less than that evoked with a single train. Neurons lacking strong outward rectification exhibited neither reliable phase-locking during high-frequency stimulation nor sensitivity to stimulus delays. These findings suggest that the firing responses of NL neurons are determined primarily by their membrane properties.

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Documento generato il 03/07/20 alle ore 01:05:28