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Titolo:
A G-PROTEIN-ACTIVATED INWARDLY RECTIFYING K+ CHANNEL (GIRK4) FROM HUMAN HIPPOCAMPUS ASSOCIATES WITH OTHER GIRK CHANNELS
Autore:
SPAUSCHUS A; LENTES KU; WISCHMEYER E; DISSMANN E; KARSCHIN C; KARSCHIN A;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM D-37077 GOTTINGEN GERMANY MAX PLANCK INST BIOPHYS CHEM D-37077 GOTTINGEN GERMANY MAX PLANCK INST EXPTL MED D-37077 GOTTINGEN GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 3, volume: 16, anno: 1996,
pagine: 930 - 938
SICI:
0270-6474(1996)16:3<930:AGIRKC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM CHANNEL; FUNCTIONAL EXPRESSION; RECEPTORS; CELLS; CLONING; OPENERS; SUBUNIT; MUSCLE;
Keywords:
INWARDLY RECTIFYING K+ CHANNELS; K-ATP CHANNELS; GIRK; G-PROTEIN-ACTIVATION HETEROOLIGOMERS; HETEROLOGOUS EXPRESSION; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A. Spauschus et al., "A G-PROTEIN-ACTIVATED INWARDLY RECTIFYING K+ CHANNEL (GIRK4) FROM HUMAN HIPPOCAMPUS ASSOCIATES WITH OTHER GIRK CHANNELS", The Journal of neuroscience, 16(3), 1996, pp. 930-938

Abstract

Transcripts of a gene, GIRK4, that encodes for a 419-amino-acid protein and shows high structural similarity to other subfamily members of G-protein-activated inwardly rectifying K+ channels (GIRK) have been identified in the human hippocampus. When expressed in Xenopus oocytes,GIRK4 yielded functional GIRK channels with activity that was enhanced by the stimulation of coexpressed serotonin 1A receptors. GIRK4 potentiated basal and agonist-induced currents mediated by other GIRK channels, possibly because of channel heteromerization. Despite the structural similarity to a putative rat K-ATP channel, no ATP sensitivity orK-ATP-typical pharmacology was observed for GIRK4 alone or GIRK4 transfected in conjunction with other GIRK channels in COS-7 cells. In ratbrain, GIRK4 is expressed together with three other subfamily members, GIRK1-3, most likely in identical hippocampal neurons. Thus, heteromerization or an unknown molecular interaction may cause the physiological diversity observed within this class of K+ channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:02:25