Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SCHIZOPHRENIA - A DISEASE OF HETEROMODAL ASSOCIATION CORTEX
Autore:
PEARLSON GD; PETTY RG; ROSS CA; TIEN AY;
Indirizzi:
JOHNS HOPKINS UNIV HOSP,DIV PSYCHIAT NEUROIMAGING,MEYER 3-166,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS UNIV,DIV PSYCHIAT NEUROIMAGING BALTIMORE MD 00000 JOHNS HOPKINS UNIV,DEPT PSYCHIAT BALTIMORE MD 00000 JOHNS HOPKINS UNIV,DEPT NEUROSCI BALTIMORE MD 00000 JOHNS HOPKINS UNIV,DEPT MENTAL HYG BALTIMORE MD 00000
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 14, anno: 1996,
pagine: 1 - 17
SICI:
0893-133X(1996)14:1<1:S-ADOH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; SUPERIOR TEMPORAL SULCUS; INFERIOR PARIETAL LOBULE; BRAIN GLUCOSE-METABOLISM; SPATIAL WORKING-MEMORY; I-123 IMP SPECT; RHESUS-MONKEY; PREFRONTAL CORTEX; BASAL GANGLIA;
Keywords:
SCHIZOPHRENIA; CEREBRAL NEOCORTEX; HETEROMODAL ASSOCIATION CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
214
Recensione:
Indirizzi per estratti:
Citazione:
G.D. Pearlson et al., "SCHIZOPHRENIA - A DISEASE OF HETEROMODAL ASSOCIATION CORTEX", Neuropsychopharmacology, 14(1), 1996, pp. 1-17

Abstract

There is considerable evidence of disturbances of multiple brain areas in schizophrenia. The clinical features and findings from pathologicand neuro-imaging studies suggest primary involvement of a system of parallel distributed networks within the neocortex-the phylogenetically recent heteromodal association cortex (HASC). There is evidence thatHASC is a family of higher-order parallel distributed networks of circuits, mediating complex representationally guided behaviors. We arguethat HASC regions are especially involved in schizophrenia. Lesions of HASC in the disease are likely to be neurodevelopmental in origin (as evidenced by such examples as reversed planum temporale asymmetry) which have been identified by magnetic resonance imaging as specific regions of disproportionately reduced local gray matter volumes, and by neuropathologic examination as cellular migration disruptions. We believe the hypothesis of preferential heteromodal cortical abnormalities has heuristic value, and briefly indicate how it opens new avenues forinvestigating this debilitating condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:09:07