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Titolo:
JUVENILE GRANULOSA-CELL TUMOR OF THE INFANTILE TESTIS - EVIDENCE OF ADUAL EPITHELIAL SMOOTH-MUSCLE DIFFERENTIATION
Autore:
PEREZATAYDE AR; JOSTE N; MULHERN H;
Indirizzi:
CHILDRENS HOSP,DEPT PATHOL,300 LONGWOOD AVE BOSTON MA 02115
Titolo Testata:
The American journal of surgical pathology
fascicolo: 1, volume: 20, anno: 1996,
pagine: 72 - 79
SICI:
0147-5185(1996)20:1<72:JGTOTI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESMOSOMAL-PLAQUE PROTEINS; VIMENTIN FILAMENTS; OVARY; ATTACHMENT;
Keywords:
SEX CORD-STROMAL TUMOR; TESTIS; NEOPLASM; INFANT; NEONATE; CHILD; IMMUNOHISTOCHEMISTRY; ELECTRON MICROSCOPY; INTERMEDIATE FILAMENTS; VIMENTIN; DESMIN; CYTOKERATIN; MUSCLE-CELL JUNCTIONS; DESMOSOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Perezatayde et al., "JUVENILE GRANULOSA-CELL TUMOR OF THE INFANTILE TESTIS - EVIDENCE OF ADUAL EPITHELIAL SMOOTH-MUSCLE DIFFERENTIATION", The American journal of surgical pathology, 20(1), 1996, pp. 72-79

Abstract

We report the ultrastructure and immunohistochemical profile of sevenjuvenile granulosa cell tumors of the infantile testis. The infants' ages ranged from 1 day to 11 months. All tumors had characteristic ultrastructure with a mixture of spindle smooth-muscle and theca cells and polygonal granulosa cells. Clusters of polygonal granulosa cells were invested by a continuous basal lamina and contained bundles of distinct cytoplasmic filaments with evenly distributed dense bodies resembling smooth muscle. These filaments were occasionally attached to well-developed, prominent desmosomes. Tumor cells had a conspicuous rough endoplasmic reticulum and Golgi complex and occasional neutral fat droplets. In all tumors, mitochondria had laminated cristae and only rarely were there cristae with a tubulovesicular pattern characteristic of steroid secreting cells. Tumor cells stained focally with low-molecular-weight cytokeratins (8,18, and 19), smooth-muscle-specific actin, desmin, and more noticeably with vimentin. These ultrastructural and immunohistochemical features of dual epithelial-mesenchymal differentiation and distinct muscle-like filaments with dense bodies are characteristic of the juvenile granulosa cell tumor of the infantile testis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:52:58