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Titolo:
DOPAMINE D-1, DOPAMINE D-2, AND PROLACTIN RECEPTOR MESSENGER-RIBONUCLEIC-ACID EXPRESSION BY THE POLYMERASE CHAIN-REACTION IN HUMAN MENINGIOMAS
Autore:
CARROLL RS; SCHRELL UMH; ZHANG JP; DASHNER K; NOMIKOS P; FAHLBUSCH R; BLACK PM;
Indirizzi:
BRIGHAM & WOMENS HOSP,NEUROSURG LABS,221 LONGWOOD AVE,ROOM 121 BOSTONMA 02115 BRIGHAM & WOMENS HOSP,BRAIN TUMOR CTR BOSTON MA 02115 CHILDRENS HOSP BOSTON MA 00000 DANA FARBER CANC INST BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT SURG BOSTON MA 02115 UNIV ERLANGEN NURNBERG,DEPT NEUROSURG W-8520 ERLANGEN GERMANY
Titolo Testata:
Neurosurgery
fascicolo: 2, volume: 38, anno: 1996,
pagine: 367 - 374
SICI:
0148-396X(1996)38:2<367:DDDDAP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; CEREBRAL MENINGIOMAS; HORMONAL DEPENDENCY; GROWTH; CELLS; CULTURE; BROMOCRIPTINE; ASSOCIATION; FRAGMENTS; NEOPLASMS;
Keywords:
DOPAMINE RECEPTORS; MENINGIOMAS; POLYMERASE CHAIN REACTION; PROLACTIN RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Carroll et al., "DOPAMINE D-1, DOPAMINE D-2, AND PROLACTIN RECEPTOR MESSENGER-RIBONUCLEIC-ACID EXPRESSION BY THE POLYMERASE CHAIN-REACTION IN HUMAN MENINGIOMAS", Neurosurgery, 38(2), 1996, pp. 367-374

Abstract

PREVIOUS STUDIES HAVE suggested the presence of high-affinity dopamine D-1 receptors and prolactin receptors in human cerebral meningiomas. In this study, using the polymerase chain reaction, we report the presence of the messenger ribonucleic acid (mRNA) for the dopamine D-1 and D-2 receptors and the prolactin receptor in meningioma tissue specimens and cell cultures derived from meningioma tissue. Dopamine D-1 receptor mRNA was present in a majority of female tissue specimens and inall male tissue specimens. D-2 receptor mRNA was detected in all specimens examined. Prolactin receptor mRNA was present in a little more than half of the female and male meningioma tumor specimens. The polymerase chain reaction products were directly sequenced to confirm the identity of these receptors in meningiomas and cell cultures. Ligand binding studies confirmed the presence of the dopamine D-1 receptor in meningioma tissue specimens. In contrast, receptor studies with the dopamine D-2 ligand [I-125]4-iodospiperone failed to detect D-2 binding inmeningioma membrane preparations. These results suggest the existenceof active dopamine D-2 receptors in cerebral meningiomas.

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Documento generato il 02/12/20 alle ore 13:34:32