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Titolo:
D-1 AND D-2 RECEPTOR REGULATION OF PREPROENKEPHALIN AND PREPRODYNORPHIN MESSENGER-RNA IN RAT STRIATUM FOLLOWING ACUTE INJECTION OF AMPHETAMINE OR METHAMPHETAMINE
Autore:
WANG JQ; MCGINTY JF;
Indirizzi:
E CAROLINA UNIV,SCH MED,DEPT ANAT & CELL BIOL GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT ANAT & CELL BIOL GREENVILLE NC 27858
Titolo Testata:
Synapse
fascicolo: 2, volume: 22, anno: 1996,
pagine: 114 - 122
SICI:
0887-4476(1996)22:2<114:DADRRO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROENKEPHALIN MESSENGER-RNA; INSITU HYBRIDIZATION HISTOCHEMISTRY; D1 DOPAMINE RECEPTOR; NUCLEUS-ACCUMBENS; GENE-EXPRESSION; STRIATONIGRAL DYNORPHIN; LOCOMOTOR-ACTIVITY; OPIOID-PEPTIDES; MOTOR-ACTIVITY; SUBSTANCE-P;
Keywords:
OPIOID; PSYCHOSTIMULANT; DOPAMINE RECEPTOR; SCH 23390; ETICLOPRIDE; NUCLEUS ACCUMBENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.Q. Wang e J.F. Mcginty, "D-1 AND D-2 RECEPTOR REGULATION OF PREPROENKEPHALIN AND PREPRODYNORPHIN MESSENGER-RNA IN RAT STRIATUM FOLLOWING ACUTE INJECTION OF AMPHETAMINE OR METHAMPHETAMINE", Synapse, 22(2), 1996, pp. 114-122

Abstract

Our previous work has demonstrated a dose-dependent induction of striatal preprodynorphin (PPD) in response to a single injection of the psychostimulants amphetamine (AMPH) or methamphetamine (METH). In the present study, dose-response effects of acute administration of these stimulants on preproenkephalin (PPE) mRNA expression in the rat striatumwere investigated with quantitative in situ hybridization histochemistry 3 h after injection. Acute AMPH or METH at equimolar doses (3.75, 7.5, 15, and 30 mu mol/kg) significantly increased PPE mRNA expressionin dorsal (caudoputamen), but not ventral (nucleus accumbens), striatum in a dose-dependent fashion. In addition, the role of D-1 and D-2 dopamine receptors in mediating AMPH- and METH-stimulated PPE and PPD expression was also evaluated by using subtype-specific antagonists. Pretreatment of rats with SCH 23390 (0.1 mg/kg, i.p.), a selective D-1 receptor antagonist, completely blocked acute AMPH (21 mu mol/kg, i.p.)- or METH (21 mu mol/kg, i.p.)-induced PPE as well as PPD mRNA expression in the caudoputamen. Pretreatment with eticlopride (0.5 mg/kg, i.p.), a selective D-2 receptor antagonist, also blocked PPD induction bythe two stimulants, but PPE induction was unaffected. Furthermore, SCH 23390 decreased, and eticlopride elevated, constitutive PPE mRNA levels in the caudoputamen. Neither antagonist had a significant effect on the basal level of PPE or PPD mRNA in the nucleus accumbens. These results demonstrate a clear dose-related responsiveness of PPE gene expression in striatal neurons in response to acute administration of amphetamines, although the intensity of the response is far less than that for striatal PPD. Furthermore, both D-1 and D-2 subtypes of dopaminereceptors mediate AMPH- and METH-stimulated striatal PPD mRNA expression, whereas D-1 receptor activation alone mediates amphetamine-stimulated PPE mRNA expression in the rat striatum. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:56:14