Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF INTERLEUKIN-4 AND VASCULAR CELL-ADHESION MOLECULE-1 IN SELECTIVE EOSINOPHIL MIGRATION INTO THE AIRWAYS IN ALLERGIC-ASTHMA
Autore:
FUKUDA T; FUKUSHIMA Y; NUMAO T; ANDO N; ARIMA M; NAKAJIMA H; SAGARA H; ADACHI T; MOTOJIMA S; MAKINO S;
Indirizzi:
DOKKYO UNIV,SCH MED,DEPT INTERNAL MED & CLIN IMMUNOL MIBU TOCHIGI 32102 JAPAN
Titolo Testata:
American journal of respiratory cell and molecular biology
fascicolo: 1, volume: 14, anno: 1996,
pagine: 84 - 94
SICI:
1044-1549(1996)14:1<84:ROIAVC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; BRONCHOALVEOLAR LAVAGE; BRONCHIAL-MUCOSA; NEUTROPHILS; EXPRESSION; ACTIVATION; LYMPHOCYTES; BASOPHILS; ADHERENCE; INCREASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
T. Fukuda et al., "ROLE OF INTERLEUKIN-4 AND VASCULAR CELL-ADHESION MOLECULE-1 IN SELECTIVE EOSINOPHIL MIGRATION INTO THE AIRWAYS IN ALLERGIC-ASTHMA", American journal of respiratory cell and molecular biology, 14(1), 1996, pp. 84-94

Abstract

Recent in vitro studies have suggested that interleukin-4 (IL-4) may be involved in the preferential migration of eosinophils into the airways in allergic asthma through its capacity to selectively increase vascular cell adhesion molecule-1 (VCAM-1) expression on vessels. To test this hypothesis, we studied the expression of VCAM-1, E-selectin, and intercellular adhesion molecule-1 (ICAM-1) on vascular endothelium in bronchial mucosal biopsies from 20 allergic asthmatics using an immunohistochemistry technique and related the observations to IL-4 levelsin bronchoalveolar lavage (BAL) fluid simultaneously obtained and to eosinophil infiltration in the bronchial mucosa. IL-4 was detectable in BAL fluid from nine subjects (range, 15.1 to 110 pg/ml in 20-fold concentrated BAL fluid) (IL-4-positive asthmatics) but unmeasurable in the remaining 11 subjects (IL-4-negative asthmatics). The IL-4-positiveasthmatics showed a significantly increased expression of VCAM-1 but not E-selectin and ICAM-1 on vessels as compared with both IL-4-negative asthmatics (P < 0.001) and diseased control subjects (P < 0.001). In asthmatics, VCAM-1 expression was positively correlated with BAL IL-4 levels (r(s) = 0.89; P < 0.0001). Moreover, there was a significant correlation between the endothelial expression of VCAM-1 and the number of eosinophils, but not neutrophils, in the bronchial submucosa (r(2) = 0.76; P < 0.001). A significant correlation was also found betweenBAL IL-4 levels and the number of eosinophils. These results suggest that IL-4 is a VCAM-1-selective activator also in human airways and the VCAM-1-dependent pathways play a role in selective migration of eosinophils into the airways in allergic asthma, and support the hypothesis described above.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:16:03