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Titolo:
DEHYDROEPIANDROSTERONE METABOLISM IN THE FEMALE RHESUS-MONKEY - ORAL VERSUS INTRAVENOUS ADMINISTRATION
Autore:
LONGCOPE C; TAST J;
Indirizzi:
UNIV MASSACHUSETTS,SCH MED,DEPT OBSTET GYNECOL,ROOM S4-721,55 LAKE AVE N WORCESTER MA 01655 UNIV MASSACHUSETTS,SCH MED,DEPT MED WORCESTER MA 01655
Titolo Testata:
Steroids
fascicolo: 1, volume: 61, anno: 1996,
pagine: 7 - 10
SICI:
0039-128X(1996)61:1<7:DMITFR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-MENOPAUSAL WOMEN; CLEARANCE RATE; DEHYDROISOANDROSTERONE SULFATE; BINDING GLOBULIN; TESTOSTERONE; ANDROGEN; ESTROGEN; DIHYDROTESTOSTERONE; ANDROSTENEDIONE; DYNAMICS;
Keywords:
DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; METABOLISM; ABSORPTION; RHESUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C. Longcope e J. Tast, "DEHYDROEPIANDROSTERONE METABOLISM IN THE FEMALE RHESUS-MONKEY - ORAL VERSUS INTRAVENOUS ADMINISTRATION", Steroids, 61(1), 1996, pp. 7-10

Abstract

Because of the biologic effects on a variety of end points reported for dehydroepiandrosterone (DHA) and its sulfate (DHAS) after oral administration, we studied the metabolism of DHA in six female rhesus monkeys after oral and after intravenous administration We administered [4-C-14]DHA p.o. and [7-H-3]DHA i.v. simultaneously,, drawing blood samples at increasingly longer intervals for 24 h. The mean +/- SE metabolic clearance rare of the intravenous DHA was 404 +/- 49 L/day. The mean metabolic clearance rate was 2,601 +/- 261 L/day after oval administration, and the calculated absorption was 16.3 +/- 2.5%. There was vapid conversion of p.o. DHA to DHAS, as the conversion ratio of the orally administered DHA measured in the blood as [4-C-14]DHAS was 63.3 +/-13.6, whereas the conversion ratio of intravenously administered DHA to DHAS was 9.3 +/- 2.0. Small amounts of DHA were measured in the blood as testosterone and androstenedione after both forms of administration. We conclude that there is marked metabolism in splanchnic tissue of orally administered DHA to DHAS prior to its entry into the bloodstream, and the absorption of DHA itself is minimal when administered bymouth to the rhesus monkey.

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Documento generato il 19/09/20 alle ore 11:30:14