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Titolo:
RECEPTOR-MEDIATED ENDOTHELIAL-CELL DYSFUNCTION IN DIABETIC VASCULOPATHY - SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS BLOCKS HYPERPERMEABILITY IN DIABETIC RATS
Autore:
WAUTIER JL; ZOUKOURIAN C; CHAPPEY O; WAUTIER MP; GUILLAUSSEAU PJ; CAO R; HORI O; STERN D; SCHMIDT AM;
Indirizzi:
HOP LARIBOISIERE,2 RUE AMBROISE PARE F-75475 PARIS 10 FRANCE UNIV PARIS 07,UNITE IMMUNOHEMATOL PARIS FRANCE UNIV PARIS 07,DEPT INTERNAL MED,INSERM U294,LAB RECH BIOL VASC & CELLULAIRE PARIS FRANCE COLUMBIA UNIV COLL PHYS & SURG,DEPT PHYSIOL MED & SURG NEW YORK NY 10032
Titolo Testata:
The Journal of clinical investigation
fascicolo: 1, volume: 97, anno: 1996,
pagine: 238 - 243
SICI:
0021-9738(1996)97:1<238:REDIDV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-MODIFIED PROTEINS; BINDING-PROTEINS; PERMEABILITY; COMPLICATIONS; MELLITUS; SURFACE; ANGIOPATHY; PREVENTION; TISSUE;
Keywords:
DIABETES; PERMEABILITY; GLYCATION; ADVANCED; GLYCATION END PRODUCT; IMMUNOGLOBULIN SUPERFAMILY RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Wautier et al., "RECEPTOR-MEDIATED ENDOTHELIAL-CELL DYSFUNCTION IN DIABETIC VASCULOPATHY - SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS BLOCKS HYPERPERMEABILITY IN DIABETIC RATS", The Journal of clinical investigation, 97(1), 1996, pp. 238-243

Abstract

Dysfunctional endothelium is associated with and, likely, predates clinical complications of diabetes mellitus, by promoting increased vascular permeability and thrombogenicity. Irreversible advanced glycationend products (AGEs), resulting from nonenzymatic glycation and oxidation of proteins or lipids, are found in plasma, vessel wall, and tissues and have been linked to the development of diabetic complications, The principal means through which AGEs exert their cellular effects isvia specific cellular receptors, one of which, receptor for AGE (RAGE), is expressed by endothelium. We report that blockade of RAGE inhibits AGE-induced impairment of endothelial barrier function, and reverses, in large part, the early vascular hyperpermeability observed in diabetic rats, Inhibition of AGE- and diabetes-mediated hyperpermeabilityby antioxidants, both in vitro and in vivo, suggested the central role of AGE-RAGE-induced oxidant stress in the development of hyperpermeability, Taken together, these data support the concept that ligation of AGEs by endothelial RAGE induces cellular dysfunction, at least in part by an oxidant-sensitive mechanism, contributing to vascular hyperpermeability in diabetes, and that RAGE is central to this pathologic process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:35:54