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Titolo:
UBIQUITIN-POSITIVE DEGENERATING NEURITES IN THE BRAIN-STEM IN PARKINSONS-DISEASE
Autore:
GAI WP; BLESSING WW; BLUMBERGS PC;
Indirizzi:
FLINDERS MED CTR,DEPT PHYSIOL BEDFORD PK SA 5042 AUSTRALIA FLINDERS UNIV S AUSTRALIA,CTR NEUROSCI,DEPT PHYSIOL ADELAIDE SA 5001 AUSTRALIA FLINDERS UNIV S AUSTRALIA,DEPT MED ADELAIDE SA 5001 AUSTRALIA INST MED & VET SCI,DEPT NEUROPATHOL ADELAIDE SA 5000 AUSTRALIA
Titolo Testata:
Brain
, volume: 118, anno: 1995,
parte:, 6
pagine: 1447 - 1459
SICI:
0006-8950(1995)118:<1447:UDNITB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; LEWY BODIES; NEURODEGENERATIVE DISEASES; CATECHOLAMINERGIC NEURONS; PEDUNCULOPONTINE NUCLEUS; SYNTHESIZING NEURONS; ALZHEIMERS-DISEASE; MEDULLA-OBLONGATA; DEPOSITS; BODY;
Keywords:
NEURODEGENERATION; NEUROFILAMENT; PATHOGENESIS; LEWY BODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
W.P. Gai et al., "UBIQUITIN-POSITIVE DEGENERATING NEURITES IN THE BRAIN-STEM IN PARKINSONS-DISEASE", Brain, 118, 1995, pp. 1447-1459

Abstract

Characteristic ubiquitin-positive, tau-negative, degenerating neurites were present in brainstem regions known to be involved in idiopathicParkinson's disease. Corresponding changes were entirely absent from controls and from the brainstems obtained from patients who had died with Alzheimer's disease, motor neuron disease and multiple system atrophy. In Parkinson's disease cases degenerating neurites were particularly striking in the dorsal motor nucleus of the vagus. in this nucleusthe density of degenerating neurites was inversely related to the duration of Parkinson's disease symptoms. Some ubiquitin-positive degenerating neurites also contained neurofilament immuno-reactivity. Howeverconfocal microscopy revealed that ubiquitin and neurofilament reactivities were located in separate regions of the degenerating neurite, suggesting that proteins other than neurofilaments may be important in the process of ubiquitination. The demonstration of ubiquitin-positive degenerating neurites in routinely prepared paraffin- embedded material particularly in the dorsal motor nucleus of the vagus, could become diagnostically useful in those Parkinson's disease cases in which Lewybodies are difficult to find. Demonstration of extensive ubiquitin-positive degenerating neurites might provide a clue to disease activity at the time of death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:53:28