Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INVESTIGATION ON THE MECHANISM OF INHIBIT ION OF INSULIN-SECRETION INDUCED BY A PERIPHERAL-TYPE BENZODIAZEPINE, 4'-CHLORDIAZEPAM
Autore:
PETIT P; CHAPAL J; MANTEGHETTI M; LOUBATIERESMARIANI MM;
Indirizzi:
FAC MED MONTPELLIER,PHARMACOL LAB,BLVD HENRI IV F-34060 MONTPELLIER FRANCE
Titolo Testata:
Comptes rendus des seances de la Societe de biologie et de ses filiales
fascicolo: 4, volume: 187, anno: 1993,
pagine: 536 - 541
SICI:
0037-9026(1993)187:4<536:IOTMOI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
FRE
Soggetto:
ADENOSINE RECEPTORS; RAT; CELLS; A1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
P. Petit et al., "INVESTIGATION ON THE MECHANISM OF INHIBIT ION OF INSULIN-SECRETION INDUCED BY A PERIPHERAL-TYPE BENZODIAZEPINE, 4'-CHLORDIAZEPAM", Comptes rendus des seances de la Societe de biologie et de ses filiales, 187(4), 1993, pp. 536-541

Abstract

We have previously shown that the selective peripheral-type benzodiazepine agonist 4'-chlordiazepam inhibited glucose-induced insulin secretion from rat pancreatic islets. The present work was designed to further investigate the mechanism of this effect. Since interactions have been described between benzodiazepines and purinergic modulators. suchas adenosine, we studied the effect of the adenosine receptor antagonist 8-phenyltheophylline. This substance, which on its own had no effect on insulin release, prevented the inhibiting effect of 4'-chlordiazepam. We then performed experiments in the presence of forskolin, which directly stimulates adenylyl-cyclase, and dibutyryl-cyclic AMP, which enhances the intracellular cAMP content. The inhibiting effect of 4'-chlordiazepam was prevented neither by forskolin nor dibutyryl-cAMP, in contrast to the inhibiting effect of adenosine, which has been previously shown to be prevented by dibutyryl-cAMP. In conclusion, the inhibiting effect of 4'-chlordiazepam on glucose-induced insulin secretion is antagonized by 8-phenyltheophylline; the signalling mechanism of this effect appears to be independent of the adenylyl cyclase/cAMP pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 15:38:56