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Titolo:
NITRIC-OXIDE IS INVOLVED IN MALE SEXUAL-BEHAVIOR OF RATS
Autore:
BENELLI A; BERTOLINI A; POGGIOLI R; CAVAZZUTI E; CALZA L; GIARDINO L; ARLETTI R;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY HESPERIA HOSP,PATHOPHYSIOL CTR NERVOUS SYST I-41100 MODENA ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 294, anno: 1995,
pagine: 505 - 510
SICI:
0014-2999(1995)294:2-3<505:NIIIMS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENILE ERECTION; OXYTOCIN; PHARMACOLOGY;
Keywords:
SEXUAL BEHAVIOR; NITRIC OXIDE (NO); NITRIC OXIDE (NO) SYNTHASE; PARAVENTRICULAR NUCLEUS; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Benelli et al., "NITRIC-OXIDE IS INVOLVED IN MALE SEXUAL-BEHAVIOR OF RATS", European journal of pharmacology, 294(2-3), 1995, pp. 505-510

Abstract

In male rats, whether sexually experienced or sexually naive, the intraperitoneal administration of L-arginine (the natural substrate for nitric oxide synthase) (10, 25, 50 mg/kg) both increased the percentageof copulating in sexually naive rats and improved the indexes of sexual performance in sexually experienced rats, whereas the intraperitoneal administration of N-G-nitro-L-arginine methyl ester (L-NAME) (a potent inhibitor of nitric oxide synthase) (10, 25, 50 mg/kg) had opposite effects. In contrast, after intracerebroventricular administration, L-arginine (25, 50, 100 mu g/rat) had no effect - whether in naive or in experienced rats - whereas L-NAME completely prevented ejaculation in naive rats, at the dose of 100 mu g/rat, but had no effect at all in experienced rats, up to the dose of 300 mu g/rat. Finally, a direct relationship seems to exist between male copulatory performance and nitric oxide synthase activity in a discrete and defined brain area, theparaventricular nucleus of the hypothalamus: indeed, nitric oxide synthase mRNA expression in this nucleus in sexually potent rats is abouttwice that in sexually impotent rats. It is concluded that nitric oxide synthase is involved in the expression of male sexual activity, in spite of some inconsistencies that are hard to interpret.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:26:29