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Titolo:
SODIUM-FLUORIDE ATTENUATES THE NEGATIVE INOTROPIC EFFECTS OF MUSCARINIC M(2) AND ADENOSINE RECEPTOR AGONISTS
Autore:
NEUMANN J; KASPAREIT G; KIRCHHEFER U; SCHOLZ H;
Indirizzi:
UNIV MUNSTER,INST PHARMAKOL & TOXIKOL,DOMAGKSTR 12 D-48149 MUNSTER GERMANY UNIV HAMBURG,KRANKENHAUS EPPENDORF,ABT ALLGEMEINE PHARMACOL D-20246 HAMBURG GERMANY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 294, anno: 1995,
pagine: 451 - 457
SICI:
0014-2999(1995)294:2-3<451:SATNIE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-PROTEIN PHOSPHORYLATION; BETA-ADRENERGIC STIMULATION; PIG VENTRICULAR MYOCARDIUM; ISLET-ACTIVATING PROTEIN; CYCLIC-AMP; ADENYLATE-CYCLASE; RAT-HEART; CHOLINERGIC INHIBITION; SARCOPLASMIC-RETICULUM; REGULATORY COMPONENT;
Keywords:
SODIUM FLUORIDE; CARBACHOL; (-)-N-6-PHENYLISOPROPYL-ADENOSINE; PHOSPHATASE; INOTROPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J. Neumann et al., "SODIUM-FLUORIDE ATTENUATES THE NEGATIVE INOTROPIC EFFECTS OF MUSCARINIC M(2) AND ADENOSINE RECEPTOR AGONISTS", European journal of pharmacology, 294(2-3), 1995, pp. 451-457

Abstract

Sodium fluoride increased the force of contraction in isolated guinea-pig papillary muscles concentration dependently, starting at 3 mmol/l. Sodium fluoride inhibited phosphorylase phosphatase activity in homogenates from guinea pig hearts, starting at 1 mmol/l. The positive inotropic effect of 3 mmol/l sodium fluoride was not accompanied by an increase in cAMP content in guinea-pig papillary muscles. In papillary muscles, carbachol or (-)-N-6-phenylisopropyladenosine reduced the positive inotropic effect of isoprenaline (10 nmol/l) or the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (60 mu mol/l). These negative inotropic effects of carbachol and (-)-N-6-phenylisopropyladenosinewere attenuated by additional sodium fluoride (3 mmol/l). It is concluded that sodium fluoride can impair the signal transduction of muscarinic M(2) (carbachol) and adenosine receptor ((-)-N-6-phenylisopropyladenosine) agonists. This effect of sodium fluoride could support the hypothesis that the cardiac effects of muscarinic M(2) and adenosine receptor agonists involve, at least in part, the activation of phosphates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:49:19