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Titolo:
SYMPATHETIC, PARASYMPATHETIC AND NONAUTONOMIC CONTRIBUTIONS TO CARDIOVASCULAR SPECTRAL POWERS IN UNANESTHETIZED SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
DAFFONCHIO A; FRANZELLI C; DIRIENZO M; CASTIGLIONI P; MANCIA G; FERRARI AU;
Indirizzi:
CTR FISIOL CLIN & IPERTENS,VIA F SFORZA 35 I-20122 MILAN ITALY MAGGIORE HOSP,CTR FISIOL CLIN & IPERTENS MILAN ITALY CNR I-20133 MILAN ITALY SEREGNO HOSP,DIV CARDIOREHABIL SEREGNO ITALY ST GERARDO HOSP,DEPT INTERNAL MED MONZA ITALY UNIV MILAN MILAN ITALY FDN YOUNG,LARC,CTR BIOENGN MILAN ITALY POLITECN MILAN I-20133 MILAN ITALY
Titolo Testata:
Journal of hypertension
fascicolo: 12, volume: 13, anno: 1995,
parte:, 2
pagine: 1636 - 1642
SICI:
0263-6352(1995)13:12<1636:SPANCT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; HEART-RATE; CONSCIOUS RATS; HEMODYNAMIC REGULATION; PULSE INTERVAL; NERVE ACTIVITY; VARIABILITY; HUMANS; BEAT;
Keywords:
BLOOD PRESSURE VARIABILITY; HEART RATE VARIABILITY; SPECTRAL ANALYSIS; WISTAR-KYOTO RATS; SPONTANEOUSLY HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A. Daffonchio et al., "SYMPATHETIC, PARASYMPATHETIC AND NONAUTONOMIC CONTRIBUTIONS TO CARDIOVASCULAR SPECTRAL POWERS IN UNANESTHETIZED SPONTANEOUSLY HYPERTENSIVE RATS", Journal of hypertension, 13(12), 1995, pp. 1636-1642

Abstract

Objective: To determine whether spectral powers of blood pressure andpulse interval can specifically reflect sympathetic and parasympathetic effects in unanesthetized, free-moving spontaneously hypertensive rats (SHR). Design: Spectral powers were observed before and after various autonomic interventions in chronically instrumented rats. Materials and methods: Chemical sympathectomy was produced in 12-week-old SHR by repeated injections of 6-hydroxydopamine, while control rats were given vehicle alone. Chronic arterial and venous catheters were inserted in the femoral artery and vein. Blood pressure was recorded beat-to-beat for 90 min in free-moving rats; further recording sessions were obtained under additional alpha-receptor blockade with phenoxybenzamineat 1 mg/kg and/or additional cholinergic blockade with atropine at 0.8 mg/kg. Off-line computer analysis (fast Fourier transform) provided estimates of low- (0.025-0.1 Hz), mid- (0.1-0.6 Hz) and high-frequency(0.8-3.0 Hz) powers for blood pressure and pulse interval over consecutive periods of 100 s. Results: The most noticeable findings were that sympathectomy produced a striking increase in the low-frequency power of blood pressure and a tendency (borderline statistical significance) to reduce the mid-frequency power of blood pressure. Additional ct-receptor blockade had no effect on any spectral power whereas additional cholinergic blockade caused a further increase in the low-frequencyblood pressure power and a drastic reduction in all pulse interval powers. Conclusions: In the unanesthetized SHR, sympathetic activity opposes low-frequency and marginally promotes mid-frequency blood pressure fluctuations; the pulse interval spectral expression of vagal effects is spread throughout the range of frequencies explored and is not confined to the high-frequency band. These data indicate that in SHR no spectral power can specifically reflect the effects of either autonomic limb.

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Documento generato il 30/11/20 alle ore 08:41:27