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Titolo:
MACROLIDES IN THE TREATMENT OF RESPIRATOR Y-TRACT INFECTIONS IN CHILDREN
Autore:
FLORET D;
Indirizzi:
HOP EDOUARD HERRIOT,UNITE URGENCE & REANIMAT PEDIAT,3 PL ARSONVAL F-69437 LYON 03 FRANCE
Titolo Testata:
Archives de pediatrie
fascicolo: 12, volume: 2, anno: 1995,
pagine: 1184 - 1191
SICI:
0929-693X(1995)2:12<1184:MITTOR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
FRE
Soggetto:
ACUTE OTITIS-MEDIA; LEGIONNAIRES-DISEASE; RANDOMIZED OPEN; ERYTHROMYCIN; AZITHROMYCIN; AMOXICILLIN; BACTERIAL; PERTUSSIS; ANTIBODY; INFANTS;
Keywords:
RESPIRATORY TRACT INFECTIONS; MACROLIDES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
D. Floret, "MACROLIDES IN THE TREATMENT OF RESPIRATOR Y-TRACT INFECTIONS IN CHILDREN", Archives de pediatrie, 2(12), 1995, pp. 1184-1191

Abstract

Macrolides are antibiotics with high intracellular comcentrations. They have a bacteriostatic activity but are also bactericides for concentrations five times greater than the minimal inhibitory concentration,concentrations in which they reach in the respiratory tract. They areusually active on Streptococcus, Neisseria, Moraxella catarrhalis, Listeria monocytogenes, Bordetella pertussis, Pasteurella multocida, Chlamydia, Mycoplasma pneumoniae, Legionella pneumophila and Helicobacterplori. They have few secondary effects, some in relation with drug interactions. Their main indications are bronchopulmonary infections dueto Mycoplasma pneumoniae. Chlamydia pneunoniae, Chlamydia trachomatisand Legionella pneumophila. They are also useful in whooping cough allowing the eradication of Bordetella pertussis in the rhinopharynx, thus limiting the dissemination of the infection in children. In amygdalitis and pharyngitis, macrolides are a good substitute in the case of allergy to penicillin. New generation of macrolides (roxithromycine, clarithromycine, dirithromycine, azithromycine) might open other interesting therapeutic perspectives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:26:28