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Titolo:
NEUROCHEMICAL EFFECTS OF L-PYROGLUTAMIC ACID
Autore:
DEMELLO CF; DELAVEGA DD; PIZUTTI LT; LOPES FP; RUBIN MA; HOMERICH JG; MELO CR; SOMER JE; SOUZA DO; WAJNER M;
Indirizzi:
UNIV FED SANTA MARIA,DEPT QUIM,CTR CIENCIAS NAT & EXATAS BR-97119900 SANTA MARIA RS BRAZIL UNIV FED SANTA MARIA,CTR CIENCIAS SAUDE,DEPT FISIOL BR-97119900 SANTAMARIA RS BRAZIL UNIV FED SANTA MARIA,CTR CIENCIAS SAUDE,DEPT PATOL BR-97119900 SANTA MARIA RS BRAZIL UNIV FED RIO GRANDE SUL,INST BIOCIENCIAS,DEPT BIOQUIM BR-90050170 PORTO ALEGRE RS BRAZIL
Titolo Testata:
Neurochemical research
fascicolo: 12, volume: 20, anno: 1995,
pagine: 1437 - 1441
SICI:
0364-3190(1995)20:12<1437:NEOLA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN INJURY; HUNTINGTONS-DISEASE; CHRONIC INFUSION; NEONATAL RATS; AMINO-ACIDS; GLUTAMATE; NEUROTOXICITY; STRIATUM; SYSTEMS; BINDING;
Keywords:
PYROGLUTAMIC ACID; ORGANIC ACIDEMIAS; NEUROTOXICITY; ADENYLATE CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Demello et al., "NEUROCHEMICAL EFFECTS OF L-PYROGLUTAMIC ACID", Neurochemical research, 20(12), 1995, pp. 1437-1441

Abstract

The effect of L-pyroglutamic acid, a metabolite that accumulates in pyroglutamic aciduria, on different neurochemical parameters was investigated in adult male Wistar rats. Glutamate binding, adenylate cyclaseactivity and G protein coupling to adenylate cyclase were assayed in the presence of the acid. L-pyroglutamic acid decreased Na+-dependent and Na+-independent glutamate binding. Basal and GMP-PNP stimulated adenylate cyclase activity were not affected by the acid. Furthermore, rats received unilateral intrastriatal injections of 10-300 nmol of buffered L-pyroglutamic acid. Vehicle (0.25 M Tris-Cl, pH 7.35-7.4) was injected into the contralateral striatum. Neurotoxic damage was assessed seven days after the injection by histological examination and by weighing both cerebral hemispheres. No difference in histology or weightcould be identified between hemispheres. These results suggest that, although capable of interfering with glutamate binding, pyroglutamate did not cause a major lesion in the present model of neurotoxicity.

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Documento generato il 11/07/20 alle ore 04:22:50