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Titolo:
PULMONARY HISTIOCYTOSIS-X - PULMONARY-FUNCTION AND EXERCISE PATHOPHYSIOLOGY
Autore:
CRAUSMAN RS; JENNINGS CA; TUDER RM; ACKERSON LM; IRVIN CG; KING TE;
Indirizzi:
NATL JEWISH CTR IMMUNOL & RESP MED,ILD SCOR PROGRAM,DEPT MED,1400 JACKSON ST DENVER CO 80206 NATL JEWISH CTR IMMUNOL & RESP MED,ILD SCOR PROGRAM,DEPT MED DENVER CO 80206 UNIV COLORADO,HLTH SCI CTR,DIV PULM SCI & CRIT CARE MED DENVER CO 00000 UNIV COLORADO,HLTH SCI CTR,DEPT MED DENVER CO 00000 UNIV COLORADO,HLTH SCI CTR,DEPT PATHOL DENVER CO 00000
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 153, anno: 1996,
pagine: 426 - 435
SICI:
1073-449X(1996)153:1<426:PH-PAE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFUSING-CAPACITY; LANGERHANS CELL; EOSINOPHILIC GRANULOMA; DEAD SPACE; LUNG; DIAGNOSIS; EMBOLISM; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Crausman et al., "PULMONARY HISTIOCYTOSIS-X - PULMONARY-FUNCTION AND EXERCISE PATHOPHYSIOLOGY", American journal of respiratory and critical care medicine, 153(1), 1996, pp. 426-435

Abstract

Pulmonary histiocytosis X (PHX) is a diffuse, smoking-related lung disease characterized pathologically by bronchocentric inflammation, cyst formation, and widespread vascular abnormalities and physiologicallyby exercise limitation. The major mechanism underlying exercise impairment in this disease has not been previously defined. Spirometry, lung volumes, lung mechanics, and exercise physiology were performed on 23 patients with PHX. Two subgroups were identified on the basis of elastic recoil: 12 subjects had an elevated coefficient of elastic recoilwith 11 demonstrating a predominant pattern of restriction, and 10 subjects had normal elastic recoil and relatively normal lung function. Exercise performance was severely limited in both subgroups (workload 53 +/- 3%). Abnormalities of ventilatory function and gas exchange were present but did not appear to be exercise-limiting in the majority of subjects. Indices reflecting pulmonary vascular function (DL(CO), baseline VD/VT, exercise VD/VT) were abnormal. Strong correlations between overall exercise performance (% predicted V overdot O(2)max) and indices of vascular involvement were present: DL(CO) (r = 0.68, p = 0.0004), baseline VD/VT (-0.65, 0.001), exercise VD/VT (-0.67, 0.0004). Similar correlations were found when exercise performance was measured by maximal workload achieved. We conclude that (1) subjects with PHX present with either normal or predominantly restrictive pulmonary physiology and that (2) exercise impairment is common and appears to reflectpulmonary vascular dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:28:48