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Titolo:
COMPARTMENTALIZED IL-8 AND ELASTASE RELEASE WITHIN THE HUMAN LUNG IN UNILATERAL PNEUMONIA
Autore:
BOUTTEN A; DEHOUX MS; SETA N; OSTINELLI J; VENEMBRE P; CRESTANI B; DOMBRET MC; DURAND G; AUBIER M;
Indirizzi:
HOP BICHAT,SERV BIOCHIM A,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT,INSERM,U408,SERV PNEUMOL F-75877 PARIS 18 FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 153, anno: 1996,
pagine: 336 - 342
SICI:
1073-449X(1996)153:1<336:CIAERW>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC FACTOR; RESPIRATORY-DISTRESS SYNDROME; HUMAN-LEUKOCYTE ELASTASE; ALPHA-1-PROTEINASE INHIBITOR; GENE-EXPRESSION; INTERLEUKIN-8; INACTIVATION; PROTEIN-1; MODEL; METALLOPROTEINASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Boutten et al., "COMPARTMENTALIZED IL-8 AND ELASTASE RELEASE WITHIN THE HUMAN LUNG IN UNILATERAL PNEUMONIA", American journal of respiratory and critical care medicine, 153(1), 1996, pp. 336-342

Abstract

Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared with that in the contralateral, noninvolved lung, and with the systemic response. Eight healthy volunteers served as controls. IL-8, total neutrophil elastase (NE), free elastase activity, alpha(1)-antitrypsin (alpha(1)-AT), and total leukocyte and neutrophil counts were evaluated in bronchoalveolar lavage fluids (BALF). Mean IL-8 concentrations in BALF from the involved lungs of the patients were significantly greater than those in BALF from thenoninvolved lung or from controls (p less than or equal to 0.001). Bycontrast, the serum IL-8 concentration was not different in patients and in controls. Total NE and alpha(1)-AT concentrations were increased in BALF from the involved lung as compared with the noninvolved lungor controls (p less than or equal to 0.001). The elastase-inhibitory capacity of alpha(1)-AT in BALF was impaired in the involved lung of seven of the 14 patients as compared with the controls, leading to freeelastase activity in the involved lung of all patients with CAP. Plasma total NE concentrations were significantly greater in the CAP patients than in the controls. IL-8 concentrations in BALF correlated positively with total leukocyte counts, absolute numbers and percentages ofneutrophils, total NE concentrations, and free elastase activity. Ourresults suggest that during unilateral CAP, locally produced IL-8 maytrigger neutrophil accumulation and activation, thus contributing to a local elastase/antielastase imbalance within the site of infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:56:07