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Titolo:
IN-VIVO INHIBITION OF HEPATITIS-B VIRUS GENE-EXPRESSION BY ANTISENSE PHOSPHOROTHIOATE OLIGONUCLEOTIDES
Autore:
MORIYA K; MATSUKURA M; KUROKAWA K; KOIKE K;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT INTERNAL MED 1,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 1,BUNKYO KU TOKYO 113 JAPAN KUMAMOTO UNIV,DEPT CHILD DEV KUMAMOTO 860 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 218, anno: 1996,
pagine: 217 - 223
SICI:
0006-291X(1996)218:1<217:IIOHVG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNODEFICIENCY VIRUS; RECOMBINANT INTERFERON-ALFA; CHRONICALLY INFECTED-CELLS; X-GENE; HEPATOCELLULAR-CARCINOMA; CONTROLLED TRIAL; LIVER-CANCER; OLIGODEOXYNUCLEOTIDES; REPLICATION; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Moriya et al., "IN-VIVO INHIBITION OF HEPATITIS-B VIRUS GENE-EXPRESSION BY ANTISENSE PHOSPHOROTHIOATE OLIGONUCLEOTIDES", Biochemical and biophysical research communications, 218(1), 1996, pp. 217-223

Abstract

While an important goal of treatment for hepatitis B is to prevent the development of hepatocellular carcinoma, there has been no effectivetherapy for it. Antisense oligodeoxynucleotide treatment could in principle inhibit hepatitis B virus gene expression and suppress tumor development. We used a mouse model for hepatocellular carcinoma, which is transgenic for the hepatitis B virus HBx gene, to study antisense phosphorothioate oligodeoxynucleotides. Among 2 series of sense and antisense oligodeoxynucleotides, only antisense sequences covering the initiation codon of the HBx gene effectively inhibited the expression of the HBx gene in the liver. Intraperitoneal injection of this antisenseoligodeoxynucleotide thrice a week for 8 weeks resulted in the prevention of preneoplastic lesion development in the liver without inflammation in the liver or developmental disturbance of the mice. Antisense phosphorothioate oligodeoxynucleotides can inhibit the expression of ahepatitis B virus gene and may be a promising method for the prevention of hepatocellular carcinoma in hepatitis B virus infection. (C) 1996 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:15:52