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Titolo:
SYNTHESIS OF CROSS-LINKED POLYPHOSPHATES AND DRUG-RELEASE
Autore:
LUO Y; ZHUO RX; FAN CL;
Indirizzi:
WUHAN UNIV,DEPT CHEM WUHAN 430072 PEOPLES R CHINA WUHAN UNIV,DEPT CHEM WUHAN 430072 PEOPLES R CHINA BEIJING UNIV,DEPT CHEM BEIJING 100871 PEOPLES R CHINA
Titolo Testata:
Gaodeng xuexiao huaxue xuebao
fascicolo: 10, volume: 16, anno: 1995,
pagine: 1633 - 1636
SICI:
0251-0790(1995)16:10<1633:SOCPAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
CHI
Keywords:
CROSS-LINKED POLYPHOSPHATE; 5-FLUOROURACIL; DRUG RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
Y. Luo et al., "SYNTHESIS OF CROSS-LINKED POLYPHOSPHATES AND DRUG-RELEASE", Gaodeng xuexiao huaxue xuebao, 16(10), 1995, pp. 1633-1636

Abstract

Ring-opening polymerizations of 2-hydro-2-oxo-1,3, 2-dioxa-phospholanand/or 2-hydro-2-oxo-1,3, 2-dioxaphosphorinane were studied using (i-Bu(3))Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained, The in vitro release of 5-fluorouracil from its single-matrix pellets, double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out inphosphate buffer solution (pH 7. 4) at 37 degrees C. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:40:50