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Titolo:
STUDIES ON WATER-SOLUBLE METALLOPORPHYRIN S AS TUMOR TARGETING MAGNETIC-RESONANCE-IMAGING CONTRAST AGENTS
Autore:
LUO Y; MEI EW; ZHUO RX;
Indirizzi:
WUHAN UNIV,DEPT CHEM WUHAN 430072 PEOPLES R CHINA WUHAN UNIV,DEPT CHEM WUHAN 430072 PEOPLES R CHINA BEIJING UNIV,DEPT CHEM BEIJING 100871 PEOPLES R CHINA WUHAN UNIV,DEPT ANALYT SCI WUHAN 430072 PEOPLES R CHINA
Titolo Testata:
Gaodeng xuexiao huaxue xuebao
fascicolo: 10, volume: 16, anno: 1995,
pagine: 1629 - 1632
SICI:
0251-0790(1995)16:10<1629:SOWMSA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
CHI
Keywords:
WATER-SOLUBLE METALLOPORPHYRIN; TUMOR TARGETING; MICROSCOPE FLUORESCENCE HADAMARD TRANSFORM 3-DIMENSIONAL IMAGE ANALYSIS; SPIN-LATTICE RELAXIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
Y. Luo et al., "STUDIES ON WATER-SOLUBLE METALLOPORPHYRIN S AS TUMOR TARGETING MAGNETIC-RESONANCE-IMAGING CONTRAST AGENTS", Gaodeng xuexiao huaxue xuebao, 16(10), 1995, pp. 1629-1632

Abstract

The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems, Compounds which affect the relaxation time could provide additionalcontrast for NMR images and are potentially useful in a clinical setting, Synthesis of targeting MRI contrast agents for specific tissue and organs is the most attractive field in the recent MRI studies, In this work, four water-soluble metalloporphyrins, Cut I)-TSPP, Mn( I)-TSPP, Cu(I)-TMAP, Mn(I)-TMAP were synthesized and their structures were confirmed by UV, IR,H-1 NMR and elemental analysis, Targeting to S-180 tumor cells of these water-soluble porphyrins was studied in vitro by microscope fluorescence-Hadamard transform three-dimensional image analysis, The spin-lattice relaxivity(R(1)) of Mn( I)-porphyrin chelate is 1, 5-2 times larger than that of Gd-DTPA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:10:36