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Titolo:
DOUBLE DISSOCIATION OF PASSIVE-AVOIDANCE AND MILK MAZE PERFORMANCE DEFICITS WITH DISCRETE LESIONS OF SUBSTANTIA INNOMINATA OR GLOBUS-PALLIDUS OF RATS
Autore:
MEYER RC; COOVER GD;
Indirizzi:
NIA,FRANCIS SCOTT KEY MED CTR,GERONTOL RES CTR,4940 EASTERN AVE BALTIMORE MD 21224 NO ILLINOIS UNIV,DEPT PSYCHOL DE KALB IL 60115
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 72, anno: 1995,
pagine: 157 - 180
SICI:
0166-4328(1995)72:1-2<157:DDOPAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; CONDITIONAL VISUAL-DISCRIMINATION; ACID-INDUCED LESIONS; IBOTENIC ACID; LATERAL HYPOTHALAMUS; EXCITOTOXIC LESIONS; QUISQUALIC ACID; NEUROTOXIC LESIONS; MEMORY IMPAIRMENTS; FOREBRAIN LESIONS;
Keywords:
SUBSTANTIA INNOMINATA; GLOBUS PALLIDUS; NUCLEUS BASALIS MAGNOCELLULARIS; PASSIVE AVOIDANCE; SPATIAL NAVIGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Meyer e G.D. Coover, "DOUBLE DISSOCIATION OF PASSIVE-AVOIDANCE AND MILK MAZE PERFORMANCE DEFICITS WITH DISCRETE LESIONS OF SUBSTANTIA INNOMINATA OR GLOBUS-PALLIDUS OF RATS", Behavioural brain research, 72(1-2), 1995, pp. 157-180

Abstract

In three experiments, small bilateral lesions of the substantia innominata (SI), globus pallidus (GP) and central nucleus of the amygdala (ACe) produced deficits in passive avoidance of drinking (dPA) or escape performance in a milk maze (MM). Severe deficits in dPA were produced by electrolytic lesions in lateral SI or rostral ACe, and by electrolytic or ibotenic acid lesions in the heart of the SI. Such lesions produced no effects on MM performance. Lesions of the rostral SI produced no, or mild, deficits in dPA and MM performance. However, lesions ofthe rostral GP produced an extreme deficit in MM performance but not dPA. The milder MM deficits produced by rSI lesions appeared to reflect a spatial navigation deficit, while the more severe impairment produced by rGP lesions appeared to represent a broader disruption of instrumental behavior. SI lesions also produced a temporary cessation of drinking and a chronic decrease in body weight, both of which were associated with impaired oromotor function. Eating and drinking deficits were less severe when lesions were more lateral or rostral in SI, and absent with lesions in rostral GP or amygdala. The most important finding, however, was a double dissociation of MM performance deficits following rostral GP lesions versus passive avoidance deficits produced by SI lesions.

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Documento generato il 06/04/20 alle ore 23:49:07