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Titolo:
NEONATAL DEPRIVATION OF MATERNAL TOUCH MAY SUPPRESS ORNITHINE DECARBOXYLASE VIA DOWN-REGULATION OF THE PROTOONCOGENES C-MYC AND MAX
Autore:
WANG SY; BARTOLOME JV; SCHANBERG SM;
Indirizzi:
DUKE UNIV,DEPT PHARMACOL,POB 3813 DURHAM NC 27710 DUKE UNIV,DEPT PHARMACOL DURHAM NC 27710
Titolo Testata:
The Journal of neuroscience
fascicolo: 2, volume: 16, anno: 1996,
pagine: 836 - 842
SICI:
0270-6474(1996)16:2<836:NDOMTM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM GROWTH-HORMONE; RAT PUPS; CELL-PROLIFERATION; STIMULATES GROWTH; GENE; EXPRESSION; TACTILE; FIBROBLASTS; JUN; FOS;
Keywords:
MATERNAL SEPARATION; ORNITHINE DECARBOXYLASE; C-MYC; MAX; IMMEDIATE-EARLY GENES; DEVELOPMENT; RAT PUP; MATERNAL TOUCH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S.Y. Wang et al., "NEONATAL DEPRIVATION OF MATERNAL TOUCH MAY SUPPRESS ORNITHINE DECARBOXYLASE VIA DOWN-REGULATION OF THE PROTOONCOGENES C-MYC AND MAX", The Journal of neuroscience, 16(2), 1996, pp. 836-842

Abstract

Previously, we have shown that short-term (1 hr) separation of neonatal rats from their mother (MS) suppresses basal ornithine decarboxylase (ODC) synthesis and tissue ODC response to trophic factors. This effect in the pup is caused by absence of maternal tactile stimulation (touch) but not from lack of maternal nutrients (food). This study was performed to examine in 10-d-old rats whether maternal touch deprivation affects expression of certain hepatic proto-oncogenes, the protein products of which are known to interact with the regulatory region of the ODC gene. Prolactin (PRL) injected subcutaneously increased hepaticODC activity as well as mRNA levels of ODC and the proto-oncogenes c-fos, c-jun, junB, junD, c-myc, and max. MS significantly suppressed PRL-induced increases in ODC enzyme activity and c-myc, mau, and ODC mRNAs but had little effect on expression of the other proto-oncogenes. PRL-induced stimulation of ODC, c-myc, and max mRNAs also was depressedin neonates placed with an anesthetized lactating dam (touch-deprived) but not in pups placed with nipple-ligated dams (food-deprived). Furthermore, unlike its effect on preweanling-age pups (<20 d old), MS did not alter expression of either ODC or c-myc mRNAs in 25-d-old pups acutely separated from their mother. These findings indicate that suppression of ODC gene transcription in the neonatal pup during MS may be mediated by downregulation of the ODC gene transactivator proto-oncogenes c-myc and mau. They are also consistent with our previous observation that lack of maternal touch, but not maternal milk, initiates the physiological alterations induced by MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:42:03