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Titolo:
MODULATION OF DOPAMINE EFFLUX IN THE NUCLEUS-ACCUMBENS AFTER CHOLINERGIC STIMULATION OF THE VENTRAL TEGMENTAL AREA IN INTACT, PEDUNCULOPONTINE TEGMENTAL NUCLEUS-LESIONED, AND LATERODORSAL TEGMENTAL NUCLEUS-LESIONED RATS
Autore:
BLAHA CD; ALLEN LF; DAS S; INGLIS WL; LATIMER MP; VINCENT SR; WINN P;
Indirizzi:
UNIV ST ANDREWS,SCH PSYCHOL ST ANDREWS KY16 9JU FIFE SCOTLAND UNIV ST ANDREWS,SCH PSYCHOL ST ANDREWS KY16 9JU FIFE SCOTLAND UNIV BRITISH COLUMBIA,DEPT PSYCHOL VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,DEPT PSYCHIAT VANCOUVER BC V6T 1Z4 CANADA DALHOUSIE UNIV,DEPT ANAT & NEUROBIOL HALIFAX NS B3H 4H7 CANADA
Titolo Testata:
The Journal of neuroscience
fascicolo: 2, volume: 16, anno: 1996,
pagine: 714 - 722
SICI:
0270-6474(1996)16:2<714:MODEIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SUBSTANTIA-NIGRA; PONTOMESENCEPHALIC TEGMENTUM; MESOPONTINE TEGMENTUM; PARS-COMPACTA; BEHAVIORAL REACTIONS; EXCITOTOXIC LESIONS; INVIVO VOLTAMMETRY; NEUROTOXIC LESIONS; MONKEY MIDBRAIN;
Keywords:
VENTRAL TEGMENTAL AREA; NUCLEUS ACCUMBENS; LATERODORSAL TEGMENTAL NUCLEUS; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; DOPAMINE; ACETYLCHOLINE; IBOTENATE; CHRONOAMPEROMETRY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Blaha et al., "MODULATION OF DOPAMINE EFFLUX IN THE NUCLEUS-ACCUMBENS AFTER CHOLINERGIC STIMULATION OF THE VENTRAL TEGMENTAL AREA IN INTACT, PEDUNCULOPONTINE TEGMENTAL NUCLEUS-LESIONED, AND LATERODORSAL TEGMENTAL NUCLEUS-LESIONED RATS", The Journal of neuroscience, 16(2), 1996, pp. 714-722

Abstract

Microinjections of the cholinergic receptor agonist nicotine and the cholinesterase inhibitor neostigmine were made into the ventral tegmental area (VTA) of urethane-anesthetized rats, and dopamine (DA) effluxin the nucleus accumbens was measured using in vivo chronoamperometry. Dose-dependent increases in the chronoamperometric signals corresponding to increased DA efflux were observed in the nucleus accumbens of normal intact rats after cholinergic stimulation of the VTA. The source of the cholinergic input to the VTA was investigated by making excitotoxic lesions in either the laterodorsal tegmental nucleus (LDTg) or the pedunculopontine tegmental nucleus (PPTg). Compared with sham-operated control animals, which showed the same response as intact, nonlesioned rats, ibotenate lesions of the LDTg attenuated the stimulatory effects of intra-VTA neostigmine on DA efflux in the nucleus accumbens. In contrast, rats with ibotenate lesions of the PPTg showed normal nucleus accumbens DA efflux after intra-VTA injections of neostigmine. Such lesions in the PPTg attenuate DA efflux in the caudate-putamen stimulated by injections of neostigmine into the substantia nigra pars compacta (SNc). The present data show that cholinergic neurons in the LDTg, but not the PPTg, regulate the activity of DA-containing neurons in the VTA, which complements previous data showing that cholinergic neurons in the PPTg regulate DA-containing neurons in the SNc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:27:19