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Titolo:
ASSESSMENT OF HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS FUNCTION IN DEXAMETHASONE-TREATED VERY-LOW-BIRTH-WEIGHT INFANTS BY A SINGLE-DOSE METYRAPONE TEST AND GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF URINARY STEROIDS
Autore:
WUDY SA; HOMOKI J; HAACK D; JUNG D; SORGO W; TELLER WM; BARTMAN P;
Indirizzi:
UNIV ULM,DEPT PEDIAT 1,PRITTWITZSTR 43 D-89075 ULM GERMANY UNIV HEIDELBERG,DEPT PHARMACOL,STEROID LAB D-69120 HEIDELBERG GERMANY
Titolo Testata:
Journal of pediatric endocrinology & metabolism
fascicolo: 4, volume: 8, anno: 1995,
pagine: 281 - 286
SICI:
0334-018X(1995)8:4<281:AOHAFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL AXIS; PRETERM INFANTS; CHILDREN;
Keywords:
HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; VERY LOW BIRTH WEIGHT INFANTS; DEXAMETHASONE; METYRAPONE TEST; STEROIDS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Wudy et al., "ASSESSMENT OF HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS FUNCTION IN DEXAMETHASONE-TREATED VERY-LOW-BIRTH-WEIGHT INFANTS BY A SINGLE-DOSE METYRAPONE TEST AND GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF URINARY STEROIDS", Journal of pediatric endocrinology & metabolism, 8(4), 1995, pp. 281-286

Abstract

In order to assess hypothalamic-pituitary-adrenocortical axis function, we conducted low and single oral dose metyrapone tests (35 mg/kg) in dexamethasone treated very low birth weight infants with bronchopulmonary dysplasia (n = 12), The responses to metyrapone of tetrahydro-11-deoxycortisol (THS) and cortisol metabolites were analyzed by gas chromatography and mass spectrometry in 24-h urinary specimens, For comparative reasons, morning plasma 11-deoxycortisol and cortisol were measured by radioimmunoassay before and after metyrapone, No side effects of metyrapone were observed in our patients, In 5 of 12 patients, no urinary THS could be stimulated after metyrapone and most of the other patients had small increases in urinary THS, These findings suggest suppressed or strongly impaired hypothalamic-pituitary-adrenocortical axis function in most patients, While the concentrations of plasma 11-deoxycortisol showed little variation, those of plasma cortisol were grossly different from the respective urinary values, We recommend steroid analysis in 24-h urinary specimens by gas chromatography and mass spectrometry, because urinary steroids provide more information and the highly specific analytical technique is independent of phenomena such as cross reactivity or matrix effects, The low and single oral dose metyrapone test in combination with urinary steroid analysis by gas chromatography and mass spectrometry therefore provides a noninvasive, convenient and safe means of evaluating the integrity of the hypothalamic-pituitary-adrenocortical axis in very low birth weight infants.

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Documento generato il 20/01/20 alle ore 16:05:19