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Titolo:
HUMAN NEONATAL RED-BLOOD-CELLS - AN EXPERIMENTAL-MODEL FOR THE STUDY OF CALCIUM-ACTIVATED POTASSIUM CHANNEL REFRACTORINESS
Autore:
SERRANI RE; GIOIA IA; CORCHS JL;
Indirizzi:
UNIV NACL ROSARIO,FAC CIENCIAS MED,CATEDRA FISIOL RA-2000 ROSARIO ARGENTINA
Titolo Testata:
Archives internationales de physiologie, de biochimie et de biophysique
fascicolo: 5, volume: 101, anno: 1993,
pagine: 297 - 301
SICI:
0778-3124(1993)101:5<297:HNR-AE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-ERYTHROCYTES; IONOPHORE A23187; K+ TRANSPORT; MEMBRANE; PHOSPHATIDYLSERINE; ENDOCYTOSIS; DEPENDENCE; HEMOLYSIS; CHLORIDE;
Keywords:
NEONATAL RED CELLS; POTASSIUM CHANNELS; HUMAN CORD BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Serrani et al., "HUMAN NEONATAL RED-BLOOD-CELLS - AN EXPERIMENTAL-MODEL FOR THE STUDY OF CALCIUM-ACTIVATED POTASSIUM CHANNEL REFRACTORINESS", ARCH I PHYS, 101(5), 1993, pp. 297-301

Abstract

To study some characteristics of calcium-activated potassium channelsfree from plasma membrane lipid perturbations, neonatal red blood cells were selected.To this end, cells not previously treated (ATP depletion and/or reversible lysis) were exposed to the ionophore A23187 in aNO3 medium with calcium. The net efflux of potassium from the cells was studied. Preincubation in a medium devoid of potassium induced a significant decrease only in the rate constant of potassium flux. The data suggest that, in the absence of plasma membrane lipid impairment, changes in internal sites reactivity with calcium ions of channel proteins would be involved in the refractoriness. This would be at variancewith channel density modifications.

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Documento generato il 08/07/20 alle ore 07:53:48