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Titolo:
DIFFERENTIAL CHOLINERGIC REGULATION OF DOPAMINE RELEASE IN THE DORSALAND VENTRAL NEOSTRIATUM OF THE RAT - AN IN-VIVO MICRODIALYSIS STUDY
Autore:
OCONNOR WT; DREW KL; UNGERSTEDT U;
Indirizzi:
KAROLINSKA INST,DIV PHARMACOL,DEPT PHYSIOL & PHARMACOL S-17177 STOCKHOLM SWEDEN UNIV ALASKA,INST ARCTIC BIOL FAIRBANKS AK 99775
Titolo Testata:
The Journal of neuroscience
fascicolo: 12, volume: 15, anno: 1995,
pagine: 8353 - 8361
SICI:
0270-6474(1995)15:12<8353:DCRODR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; ACETYLCHOLINE-RELEASE; MUSCARINIC RECEPTORS; BRAIN DIALYSIS; PHENOTYPICAL CHARACTERIZATION; ENDOGENOUS ACETYLCHOLINE; CORPUS STRIATUM; BASAL GANGLIA; D-2 RECEPTORS; H-3 DOPAMINE;
Keywords:
NEOSTIGMINE; DOPAMINE; HALOPERIDOL; MICRODIALYSIS; NEOSTRIATUM; DORSOLATERAL; FUNDUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
W.T. Oconnor et al., "DIFFERENTIAL CHOLINERGIC REGULATION OF DOPAMINE RELEASE IN THE DORSALAND VENTRAL NEOSTRIATUM OF THE RAT - AN IN-VIVO MICRODIALYSIS STUDY", The Journal of neuroscience, 15(12), 1995, pp. 8353-8361

Abstract

We used in vivo microdialysis to investigate the effects of local perfusion with the AChE inhibitor neostigmine on the basal and haloperidol evoked increase in dialysate dopamine levels in the dorsolateral andfundus striata of the bilaterally implanted halothane anaesthetized rat. In the absence of neostigmine basal dopamine was consistently higher in the dorsolateral striatum compared with the fundus striati. Local perfusion with neostigmine (10 and 100 mu M) increased basal dopamine in the fundus striati compared to the contralateral (control) side but not in the dorsolateral striatum. In the absence of neostigmine haloperidol (0.05-0.5 mg/kg, s.c.) increased dopamine release in both thedorsolateral and fundus striata. However, local perfusion with neostigmine (10 mu M) attenuated this increase in the dorsolateral striatum at all doses of haloperidol while only the effect of the highest (0.5 mg/kg) dose of haloperidol was counteracted in the fundus striati. Both the basal and haloperidol (0.25 mg/kg) induced increase in dopamine release in the control (no neostigmine) and neostigmine (+10 mu M) treated dorsolateral striata were abolished following local perfusion with tetrodotoxin (1 mu M). The data demonstrate that the introduction ofneostigmine into the neostriatum selectively increases basal DA levels in the fundus striati and strongly counteracts the haloperidol evoked DA release in the dorsolateral striatum and thus provide strong evidence for a differential cholinergic regulation of striatal DA release in vivo. In addition, we demonstrate that the stimulatory and inhibitory effects of neostigmine operate independently and have a regional specificity within the neostriatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:57:05