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Titolo:
ISOTHERMAL MICROCALORIMETRY FOR THE CHARACTERIZATION OF INTERACTIONS BETWEEN DRUGS AND BIOLOGICAL-MATERIALS
Autore:
WADSO I;
Indirizzi:
LUND UNIV,CTR CHEM,POB 124 S-22100 LUND SWEDEN
Titolo Testata:
Thermochimica acta
, volume: 267, anno: 1995,
pagine: 45 - 59
SICI:
0040-6031(1995)267:<45:IMFTCO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLIGHTLY SOLUBLE GASES; T-LYMPHOMA CELLS; FLOW MICROCALORIMETRY; ANTINEOPLASTIC DRUGS; HEAT-CAPACITY; DISSOLUTION; BINDING; CALORIMETRY; VESSEL; WATER;
Keywords:
ISOTHERMAL MICROCALORIMETRY; DRUG; BIOLOGICAL MATERIAL; INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
I. Wadso, "ISOTHERMAL MICROCALORIMETRY FOR THE CHARACTERIZATION OF INTERACTIONS BETWEEN DRUGS AND BIOLOGICAL-MATERIALS", Thermochimica acta, 267, 1995, pp. 45-59

Abstract

Studies of interactions between drugs and biological material form a broad application area for isothermal microcalorimetry. Characterization of binding of drugs and related compounds to well-defined biological substances by use of titration microcalorimetry is a very important area. This technique has now been taken into use in practical work (''rational drug design'') by several laboratories in the pharmaceutical industry. More fundamental studies of solute-solvent interactions for drugs and for simple model systems should be encouraged. Microcalorimetric techniques suitable for investigations of the effect of drugs on microorganisms and animal cellular systems have been much developed during recent years. However, few scientific groups are presently activein this field and it seems as if the technique has not yet been adopted by R&D laboratories in the pharmaceutical industry or in applied clinical work.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:08:06